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IPR010431 is a Fascin.
<p>This entry represents fascin (FSCN) and its homologues, including FSCN1/2/3 from mammals and protein singed from fruit flies. Fascin is a globular actin cross-linking protein, which functions in forming parallel actin bundles in cell protrusions that are key specialisations of the plasma membrane for environmental guidance and cell migration [[cite:PUB00071711]]. Human FSCN1 organises filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Overexpression of fascin has been linked to a more aggressive clinical course of cancer [[cite:PUB00071711]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Actin filament organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. | ||
| Molecular function | Actin filament binding | Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable glucan 1,3-beta-glucosidase A-like [Cicer arietinum] gi|502140084|ref|XP_004504050.1| | 7 | ||
| – | PREDICTED: glucan 1,3-beta-glucosidase A-like [Glycine max] gi|356548252|ref|XP_003542517.1| | 16 | ||
| – | PREDICTED: glucan 1,3-beta-glucosidase A-like [Glycine max] gi|356548252|ref|XP_003542517.1| | 10 | ||
| – | PREDICTED: probable glucan 1,3-beta-glucosidase A-like [Glycine max] gi|356525499|ref|XP_003531362.1| | 14 | ||
| – | PREDICTED: probable glucan 1,3-beta-glucosidase A-like [Cicer arietinum] gi|502140084|ref|XP_004504050.1| | 9 | ||
| – | PREDICTED: probable glucan 1,3-beta-glucosidase A-like isoform X2 [Cicer arietinum] gi|502135628|ref|XP_004502399.1| | 14 | ||
| – | Glucan 1,3-beta-glucosidase [Medicago truncatula] gi|357463267|ref|XP_003601915.1| | 25 | ||
| – | Glucan 1,3-beta-glucosidase [Medicago truncatula] gi|357489413|ref|XP_003614994.1| | 10 | ||
| – | PREDICTED: glucan 1,3-beta-glucosidase A-like [Glycine max] gi|356548252|ref|XP_003542517.1| | 16 | ||
| – | PREDICTED: probable glucan 1,3-beta-glucosidase A-like [Glycine max] gi|356548266|ref|XP_003542524.1| | 17 | ||
| – | PREDICTED: probable glucan 1,3-beta-glucosidase A-like [Glycine max] gi|356525499|ref|XP_003531362.1| | 10 | ||
| – | PREDICTED: probable glucan 1,3-beta-glucosidase A-like [Glycine max] gi|356525499|ref|XP_003531362.1| | 9 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT4G16680.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|B0XN12|EXGA_ASPFC Probable glucan 1,3-beta-glucosidase A; TrEMBL-Plants: tr|I1LW02|I1LW02_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0148100 | 15 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT3G04490.1 exportin-4 protein; Swiss-Prot: sp|Q5B5X8|EXGA_EMENI Probable glucan 1,3-beta-glucosidase A; TrEMBL-Plants: tr|G7KA50|G7KA50_MEDTR Glycoside hydrolase family 5 protein; Found in the gene: LotjaGi1g1v0148200_LC | 9 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT5G66460.1 Glycosyl hydrolase superfamily protein; Swiss-Prot: sp|B0XN12|EXGA_ASPFC Probable glucan 1,3-beta-glucosidase A; TrEMBL-Plants: tr|I1LW02|I1LW02_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0148300 | 15 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT3G26130.2 Cellulase (glycosyl hydrolase family 5) protein; Swiss-Prot: sp|B0XN12|EXGA_ASPFC Probable glucan 1,3-beta-glucosidase A; TrEMBL-Plants: tr|G7KA50|G7KA50_MEDTR Glycoside hydrolase family 5 protein; Found in the gene: LotjaGi1g1v0148400 | 15 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT3G26130.3 Cellulase (glycosyl hydrolase family 5) protein; Swiss-Prot: sp|B0XN12|EXGA_ASPFC Probable glucan 1,3-beta-glucosidase A; TrEMBL-Plants: tr|G7KA50|G7KA50_MEDTR Glycoside hydrolase family 5 protein; Found in the gene: LotjaGi1g1v0148400 | 8 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT3G20080.1 cytochrome P450, family 705, subfamily A, polypeptide 15; Swiss-Prot: sp|Q5B5X8|EXGA_EMENI Probable glucan 1,3-beta-glucosidase A; TrEMBL-Plants: tr|I1K4L7|I1K4L7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0400000 | 18 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT1G13130.1 Cellulase (glycosyl hydrolase family 5) protein; Swiss-Prot: sp|Q96V64|EXG_BLUGR Glucan 1,3-beta-glucosidase; TrEMBL-Plants: tr|I3SE04|I3SE04_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0053600 | 15 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT1G13130.1 Cellulase (glycosyl hydrolase family 5) protein; Swiss-Prot: sp|Q5B5X8|EXGA_EMENI Probable glucan 1,3-beta-glucosidase A; TrEMBL-Plants: tr|I3SE04|I3SE04_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0053600 | 15 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT5G01930.1 Glycosyl hydrolase superfamily protein; Swiss-Prot: sp|B0XN12|EXGA_ASPFC Probable glucan 1,3-beta-glucosidase A; TrEMBL-Plants: tr|K7MPD7|K7MPD7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0090200 | 22 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT5G01930.1 Glycosyl hydrolase superfamily protein; Swiss-Prot: sp|B0XN12|EXGA_ASPFC Probable glucan 1,3-beta-glucosidase A; TrEMBL-Plants: tr|V7D1X4|V7D1X4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0090200 | 22 | ||
| – | Glucan 1,3-beta-glucosidase; TAIR: AT4G39170.1 Sec14p-like phosphatidylinositol transfer family protein; Swiss-Prot: sp|B0XN12|EXGA_ASPFC Probable glucan 1,3-beta-glucosidase A; TrEMBL-Plants: tr|V7D1X4|V7D1X4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0090500 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 4.35 |