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IPR024904 is a Ornithine carbamoyltransferase.
<p>Ornithine carbamoyltransferases catalyse the production of citrulline from carbamoyl-phosphate and ornithine [[cite:PUB00001795]]. This reaction is part of the arginine biosynthetic pathway, and in some organisms the reaction is also part of the arginine deaminase pathway [[cite:PUB00001352]]. In most prokaryotes, and some lower eukaryotes, the enzyme is found in the cytoplasm, but in higher eukaryotes, such as mammals, the enzyme is found in the mitochondrial matrix and functions as part of the urea cycle. In most organisms analysed to date, the enzyme has been shown to consist of a trimer of identical or nonidentical subunits [[cite:PUB00001353]]. Extensive similarity has been found within the ornithine carbamoyltransferase family, some of the conserved areas being important in catalysis [[cite:PUB00003720]]. The C-terminal region of these enzymes contains a highly conserved Cys residue (in a His-Cys-Lys-Pro motif) implicated in ornithine binding [[cite:PUB00001353]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Ornithine carbamoyltransferase activity | Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. | ||
| Biological process | Ornithine metabolic process | The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ornithine carbamoyltransferase, chloroplastic-like [Glycine max] gi|356510161|ref|XP_003523808.1| | 14 | ||
| – | Ornithine carbamoyltransferase; TAIR: AT1G75330.1 ornithine carbamoyltransferase; Swiss-Prot: sp|Q43814|OTC_PEA Ornithine carbamoyltransferase, chloroplastic; TrEMBL-Plants: tr|I3SIH2|I3SIH2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0420900 | 16 | ||
| – | Ornithine carbamoyltransferase; TAIR: AT1G75330.1 ornithine carbamoyltransferase; Swiss-Prot: sp|Q43814|OTC_PEA Ornithine carbamoyltransferase, chloroplastic; TrEMBL-Plants: tr|I3SZL4|I3SZL4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0014100 | 16 | ||
| – | Ornithine carbamoyltransferase; TAIR: AT1G75330.1 ornithine carbamoyltransferase; Swiss-Prot: sp|Q43814|OTC_PEA Ornithine carbamoyltransferase, chloroplastic; TrEMBL-Plants: tr|I3SZL4|I3SZL4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0014100 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00658 | TIGRFAM | 1 | 25.00 |