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IPR006130 is a Aspartate/ornithine carbamoyltransferase.
<p>This family contains two related enzymes:</p> <ol><li>Aspartate carbamoyltransferase ([ec:2.1.3.2]) (ATCase) catalyses the conversion of aspartate and carbamoyl phosphate to carbamoylaspartate, the second step in the<i>de novo</i>biosynthesis of pyrimidine nucleotides [[cite:PUB00002421]]. In prokaryotes ATCase consists of two subunits: a catalytic chain (gene pyrB) and a regulatory chain (gene pyrI), while in eukaryotes it is a domain in a multi-functional enzyme (called URA2 in yeast, rudimentary in Drosophila, and CAD in mammals [[cite:PUB00000720]]) that also catalyses other steps of the biosynthesis of pyrimidines [[cite:PUB00074256]].</li> <li>Ornithine carbamoyltransferase ([ec:2.1.3.3]) (OTCase) catalyses the conversion of ornithine and carbamoyl phosphate to citrulline. In mammals, this enzyme participates in the urea cycle [[cite:PUB00000710]] and is located in the mitochondrial matrix. In prokaryotes and eukaryotic microorganisms it is involved in the biosynthesis of arginine. In some bacterial species it is also involved in the degradation of arginine [[cite:PUB00001352]] (the arginine deaminase pathway).</li></ol> <p>It has been shown [[cite:PUB00004607]] that these two enzymes are evolutionary related. The predicted secondary structure of both enzymes are similar and there are some regions of sequence similarities. One of these regions includes three residues which have been shown, by crystallographic studies [[cite:PUB00004604]], to be implicated in binding the phosphoryl group of carbamoyl phosphate.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Cellular amino acid metabolic process | The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells. | ||
| Molecular function | Amino acid binding | Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents. | ||
| Molecular function | Carboxyl- or carbamoyltransferase activity | Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ornithine carbamoyltransferase, chloroplastic-like [Glycine max] gi|356510161|ref|XP_003523808.1| | 14 | ||
| – | PREDICTED: aspartate carbamoyltransferase 1, chloroplastic-like [Glycine max] gi|356501558|ref|XP_003519591.1| | 21 | ||
| – | Ornithine carbamoyltransferase [Canavalia lineata] gi|6578122|gb|AAF17704.1|AF033561_1 | 8 | ||
| – | Aspartate carbamoyltransferase; TAIR: AT3G20330.1 PYRIMIDINE B; Swiss-Prot: sp|Q43086|PYRB1_PEA Aspartate carbamoyltransferase 1, chloroplastic; TrEMBL-Plants: tr|I1JJC4|I1JJC4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0025700 | 22 | ||
| – | Aspartate carbamoyltransferase; TAIR: AT3G20330.1 PYRIMIDINE B; Swiss-Prot: sp|Q43086|PYRB1_PEA Aspartate carbamoyltransferase 1, chloroplastic; TrEMBL-Plants: tr|I1JJC4|I1JJC4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0025700 | 16 | ||
| – | Aspartate carbamoyltransferase; TAIR: AT3G20330.1 PYRIMIDINE B; Swiss-Prot: sp|Q43086|PYRB1_PEA Aspartate carbamoyltransferase 1, chloroplastic; TrEMBL-Plants: tr|I1JJC4|I1JJC4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0025700 | 22 | ||
| – | Ornithine carbamoyltransferase; TAIR: AT1G75330.1 ornithine carbamoyltransferase; Swiss-Prot: sp|Q43814|OTC_PEA Ornithine carbamoyltransferase, chloroplastic; TrEMBL-Plants: tr|I3SIH2|I3SIH2_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0420900 | 16 | ||
| – | Ornithine carbamoyltransferase; TAIR: AT1G75330.1 ornithine carbamoyltransferase; Swiss-Prot: sp|Q43814|OTC_PEA Ornithine carbamoyltransferase, chloroplastic; TrEMBL-Plants: tr|I3SZL4|I3SZL4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0014100 | 16 | ||
| – | Ornithine carbamoyltransferase; TAIR: AT1G75330.1 ornithine carbamoyltransferase; Swiss-Prot: sp|Q43814|OTC_PEA Ornithine carbamoyltransferase, chloroplastic; TrEMBL-Plants: tr|I3SZL4|I3SZL4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0014100 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00658 | TIGRFAM | 1 | 11.11 |