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IPR024990

Source: InterPro

Description

IPR024990 is a Anaphase-promoting complex subunit 1.

<p>Apc1 is the largest of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [[cite:PUB00091489], [cite:PUB00057287], [cite:PUB00055977], [cite:PUB00098994]]. Infection of human fibroblasts with human cytomegalovirus (HCMV) leads to cell cycle dysregulation, which is associated with the inactivation of the anaphase-promoting complex [[cite:PUB00057288]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0005680
Cellular component Anaphase-promoting complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj2g3v2760040.1
– PREDICTED: anaphase-promoting complex subunit 1-like [Cicer arietinum] gi|502097705|ref|XP_004491057.1|
Domains
3
Lj2g3v2770090.1
– PREDICTED: anaphase-promoting complex subunit 1-like [Cicer arietinum] gi|502097705|ref|XP_004491057.1|
Domains
2
LotjaGi1g1v0076600.1
– Anaphase-promoting complex subunit 1; TAIR: AT5G05560.2 E3 ubiquitin ligase; Swiss-Prot: sp|Q9FFF9|APC1_ARATH Anaphase-promoting complex subunit 1; TrEMBL-Plants: tr|G7K258|G7K258_MEDTR Anaphase-promoting complex subunit 1; Found in the gene: LotjaGi1g1v0076600
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
TRANSMEMBRANE Phobius 1 33.33