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GO:0031461

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Cullin-RING ubiquitin ligase complex
Full defintion Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.
Subterm of

Relationships

The relationship of GO:0031461 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Function and regulation of cullin-RING ubiquitin ligases.Petroski MD, Deshaies RJ
Nat Rev Mol Cell Biol. 2005 Jan; 6 (1): 9–20.PMID: 15688063

Cullin-RING complexes comprise the largest known class of ubiquitin ligases. Owing to the great diversity of their substrate-receptor subunits, it is possible that there are hundreds of distinct cullin-RING ubiquitin ligases in eukaryotic cells, which establishes these enzymes as key mediators of post-translational protein regulation. In this review, we focus on the composition, regulation and function of cullin-RING ligases, and describe how these enzymes can be characterized by a set of general principles.

Associated Lotus transcripts 6

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
LotjaGi6g1v0310200.1
– Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A0S3S3A0|A0A0S3S3A0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0310200
GO terms
3
LotjaGi6g1v0310200.2
– Cullin; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200
GO terms
3
LotjaGi6g1v0310200.4
– Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|V7BPK5|V7BPK5_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0310200
GO terms
3
LotjaGi6g1v0310200.5
– Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200
GO terms
3
LotjaGi6g1v0310200.6
– Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200
GO terms
3
LotjaGi6g1v0310200.7
– Cullin, putative; TAIR: AT5G46210.1 cullin4; Swiss-Prot: sp|Q8LGH4|CUL4_ARATH Cullin-4; TrEMBL-Plants: tr|A0A151RWC9|A0A151RWC9_CAJCA Cullin-4B; Found in the gene: LotjaGi6g1v0310200
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0031625
Molecular function Ubiquitin protein ligase binding 1 16.67