Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message

GO:0005680

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Anaphase-promoting complex
Full defintion A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B.
Subterm of

Relationships

The relationship of GO:0005680 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

A force layout showing the ancestor tree for GO:0005680, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

  • Drag and drop nodes to manually position (i.e. fix) them
  • Double click on a node to unfix the node
  • Press Alt and double click to visit the page containing further details of a GO term
  • Right clicking on a node will reveal a context menu

Controls

Force layout

Every force layout is different—we have picked a set of parameters which suits most GO ancestor tree chart well. If you mess something up—don't worry: hitting the "reset view" button above will reset the chart to its default layout.

Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCvw
PMID
SCF and Cullin/Ring H2-based ubiquitin ligases.Deshaies RJ
Annu Rev Cell Dev Biol. 1999; 15 (): 435–67.PMID: 10611969

Protein degradation is deployed to modulate the steady-state abundance of proteins and to switch cellular regulatory circuits from one state to another by abrupt elimination of control proteins. In eukaryotes, the bulk of the protein degradation that occurs in the cytoplasm and nucleus is carried out by the 26S proteasome. In turn, most proteins are thought to be targeted to the 26S proteasome by covalent attachment of a multiubiquitin chain. Ubiquitination of proteins requires a multienzyme system. A key component of ubiquitination pathways, the ubiquitin ligase, controls both the specificity and timing of substrate ubiquitination. This review is focused on a conserved ubiquitin ligase complex known as SCF that plays a key role in marking a variety of regulatory proteins for destruction by the 26S proteasome.

Associated Lotus transcripts 20

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0201039.1
– PREDICTED: anaphase-promoting complex subunit 15-like isoform X1 [Cicer arietinum] gi|502133743|ref|XP_004501876.1|
GO terms
2
Lj0g3v0281769.1
– PREDICTED: anaphase-promoting complex subunit 8-like [Cicer arietinum] gi|502078646|ref|XP_004486012.1|
GO terms
2
Lj2g3v2760040.1
– PREDICTED: anaphase-promoting complex subunit 1-like [Cicer arietinum] gi|502097705|ref|XP_004491057.1|
GO terms
1
Lj2g3v2770090.1
– PREDICTED: anaphase-promoting complex subunit 1-like [Cicer arietinum] gi|502097705|ref|XP_004491057.1|
GO terms
1
LotjaGi1g1v0044200.1
– Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|V7B6H8|V7B6H8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0044200
GO terms
1
LotjaGi1g1v0044200.2
– Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0S3RJT4|A0A0S3RJT4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0044200
GO terms
1
LotjaGi1g1v0044200.3
– Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0044200
GO terms
1
LotjaGi1g1v0044200.4
– Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0044200
GO terms
1
LotjaGi1g1v0076600.1
– Anaphase-promoting complex subunit 1; TAIR: AT5G05560.2 E3 ubiquitin ligase; Swiss-Prot: sp|Q9FFF9|APC1_ARATH Anaphase-promoting complex subunit 1; TrEMBL-Plants: tr|G7K258|G7K258_MEDTR Anaphase-promoting complex subunit 1; Found in the gene: LotjaGi1g1v0076600
GO terms
1
LotjaGi1g1v0196500.1
– Peptide chain release factor 2; TAIR: AT5G63135.1 transcription termination factor; Swiss-Prot: sp|Q54GU0|ARSB_DICDI Putative transporter arsB; TrEMBL-Plants: tr|A0A151TRF8|A0A151TRF8_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0196500
GO terms
2
LotjaGi1g1v0738900.1
– Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A151QXF2|A0A151QXF2_CAJCA Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900
GO terms
1
LotjaGi1g1v0738900.2
– Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A151QXF2|A0A151QXF2_CAJCA Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900
GO terms
1
LotjaGi1g1v0738900.3
– Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|V7B6H8|V7B6H8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0738900
GO terms
1
LotjaGi1g1v0738900.4
– Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900
GO terms
1
LotjaGi1g1v0738900.5
– Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0S3RJT4|A0A0S3RJT4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0738900
GO terms
1
LotjaGi1g1v0738900.6
– Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|V7B6H8|V7B6H8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0738900
GO terms
1
LotjaGi1g1v0738900.7
– Anaphase-promoting complex subunit 5; TAIR: AT1G06590.1 anaphase-promoting complex subunit; Swiss-Prot: sp|Q8H1U4|APC5_ARATH Anaphase-promoting complex subunit 5; TrEMBL-Plants: tr|A0A0B2PRE7|A0A0B2PRE7_GLYSO Anaphase-promoting complex subunit 5; Found in the gene: LotjaGi1g1v0738900
GO terms
1
LotjaGi3g1v0298300.1
– Anaphase-promoting complex subunit 8; TAIR: AT3G48150.1 anaphase-promoting complex subunit 8; Swiss-Prot: sp|Q9STS3|CDC23_ARATH Anaphase-promoting complex subunit 8; TrEMBL-Plants: tr|I1LGI1|I1LGI1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0298300
GO terms
2
LotjaGi4g1v0049700.1
– Anaphase-promoting complex subunit 4; TAIR: AT4G21530.1 Transducin/WD40 repeat-like superfamily protein; Swiss-Prot: sp|O65418|APC4_ARATH Anaphase-promoting complex subunit 4; TrEMBL-Plants: tr|A0A151T237|A0A151T237_CAJCA Anaphase-promoting complex subunit 4; Found in the gene: LotjaGi4g1v0049700
GO terms
3
LotjaGi4g1v0119200.1
– Anaphase-promoting complex subunit 10; TAIR: AT2G18290.1 anaphase promoting complex 10; Swiss-Prot: sp|Q9ZPW2|APC10_ARATH Anaphase-promoting complex subunit 10; TrEMBL-Plants: tr|I3SBG7|I3SBG7_LOTJA Anaphase-promoting complex subunit 10; Found in the gene: LotjaGi4g1v0119200
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0031145
Biological process Anaphase-promoting complex-dependent catabolic process 1 5.00