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IPR026258 is a Signal recognition particle subunit SRP68.
<p>The signal recognition particle (SRP) is a large ribonucleoprotein complex that targets secretory and membrane proteins to the endoplasmic reticulum membrane [[cite:PUB00060307], [cite:PUB00100261]]. The mammalian SRP contains a 303-nucleotide SRP RNA and six proteins, named SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72. Among them, the two largest, SRP68 and SRP72, form a stable SRP68/72 heterodimer of unknown structure, which is required for sorting secretory proteins [[cite:PUB00060304]]. SRP68 binds to SRP RNA directly, while SRP72 binds the SRP RNA largely via non-specific electrostatic interaction. The binding of SRP72 with SRP RNA enhances the affinity of SRP68 for the RNA.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Signal recognition particle binding | Interacting selectively and non-covalently with the signal recognition particle. | ||
| Cellular component | Signal recognition particle, endoplasmic reticulum targeting | A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. | ||
| Biological process | SRP-dependent cotranslational protein targeting to membrane | The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. | ||
| Molecular function | 7S RNA binding | Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP). | ||
| Molecular function | Endoplasmic reticulum signal peptide binding | Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: signal recognition particle 68 kDa protein-like isoform X1 [Cicer arietinum] gi|502139530|ref|XP_004503804.1| | 5 | ||
| – | PREDICTED: signal recognition particle 68 kDa protein-like isoform X1 [Cicer arietinum] gi|502139530|ref|XP_004503804.1| | 5 | ||
| – | PREDICTED: signal recognition particle 68 kDa protein-like isoform X1 [Cicer arietinum] gi|502139530|ref|XP_004503804.1| | 5 | ||
| – | PREDICTED: signal recognition particle 68 kDa protein-like isoform X1 [Cicer arietinum] gi|502139530|ref|XP_004503804.1| | 5 | ||
| – | Signal recognition particle subunit SRP68; TAIR: AT5G61970.1 signal recognition particle-related / SRP-like protein; Swiss-Prot: sp|Q8BMA6|SRP68_MOUSE Signal recognition particle subunit SRP68; TrEMBL-Plants: tr|G7LIT8|G7LIT8_MEDTR Signal recognition particle subunit SRP68; Found in the gene: LotjaGi4g1v0421900 | 8 | ||
| – | Signal recognition particle subunit SRP68; TAIR: AT5G61970.1 signal recognition particle-related / SRP-like protein; Swiss-Prot: sp|Q8BMA6|SRP68_MOUSE Signal recognition particle subunit SRP68; TrEMBL-Plants: tr|G7LIT8|G7LIT8_MEDTR Signal recognition particle subunit SRP68; Found in the gene: LotjaGi4g1v0421900 | 8 | ||
| – | Signal recognition particle subunit SRP68; TAIR: AT5G61970.1 signal recognition particle-related / SRP-like protein; Swiss-Prot: sp|Q8BMA6|SRP68_MOUSE Signal recognition particle subunit SRP68; TrEMBL-Plants: tr|G7LIT8|G7LIT8_MEDTR Signal recognition particle subunit SRP68; Found in the gene: LotjaGi4g1v0421900 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd15481 | CDD | 1 | 14.29 |