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IPR026791 is a Dedicator of cytokinesis.
<p>DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases [[cite:PUB00014935]]. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [[cite:PUB00073863], [cite:PUB00073862]]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) [[cite:PUB00014935]]. All DOCKs contain two homology domains: the DHR-1 (Dock homology region-1), also called CZH1 (CED-5, Dock180, and MBC-zizimin homology 1), and DHR-2 (also called CZH2 or Docker).</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Guanyl-nucleotide exchange factor activity | Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase. | ||
| Biological process | Small GTPase mediated signal transduction | Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: dedicator of cytokinesis protein 7-like [Glycine max] gi|356554751|ref|XP_003545706.1| | 3 | ||
| – | PREDICTED: dedicator of cytokinesis protein 6-like [Cicer arietinum] gi|502158508|ref|XP_004511179.1| | 8 | ||
| – | PREDICTED: dedicator of cytokinesis protein 11-like [Glycine max] gi|356525602|ref|XP_003531413.1| | 6 | ||
| – | PREDICTED: dedicator of cytokinesis protein 11-like [Glycine max] gi|356525602|ref|XP_003531413.1| | 5 | ||
| – | Dedicator of cytokinesis; TAIR: AT4G16340.1 guanyl-nucleotide exchange factors;GTPase binding;GTP binding protein; Swiss-Prot: sp|Q8SAB7|SPK1_ARATH Guanine nucleotide exchange factor SPIKE 1; TrEMBL-Plants: tr|K7MCT0|K7MCT0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0299000 | 19 | ||
| – | Dedicator of cytokinesis; TAIR: AT4G16340.1 guanyl-nucleotide exchange factors;GTPase binding;GTP binding protein; Swiss-Prot: sp|Q8SAB7|SPK1_ARATH Guanine nucleotide exchange factor SPIKE 1; TrEMBL-Plants: tr|A0A0R0IQP1|A0A0R0IQP1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0299000 | 16 | ||
| – | Dedicator of cytokinesis; TAIR: AT4G16340.1 guanyl-nucleotide exchange factors;GTPase binding;GTP binding protein; Swiss-Prot: sp|Q8SAB7|SPK1_ARATH Guanine nucleotide exchange factor SPIKE 1; TrEMBL-Plants: tr|A0A0R0G4P9|A0A0R0G4P9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0299000 | 18 | ||
| – | Dedicator of cytokinesis; TAIR: AT4G16340.1 guanyl-nucleotide exchange factors;GTPase binding;GTP binding protein; Swiss-Prot: sp|Q8SAB7|SPK1_ARATH Guanine nucleotide exchange factor SPIKE 1; TrEMBL-Plants: tr|K7MCT0|K7MCT0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0299000 | 19 | ||
| – | Dedicator of cytokinesis; TAIR: AT4G16340.1 guanyl-nucleotide exchange factors;GTPase binding;GTP binding protein; Swiss-Prot: sp|Q8SAB7|SPK1_ARATH Guanine nucleotide exchange factor SPIKE 1; TrEMBL-Plants: tr|A0A0R0G4P9|A0A0R0G4P9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0299000 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 11.11 |