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IPR027235

Source: InterPro

Description

IPR027235 is a Prefoldin subunit 2.

<p>This entry represents prefoldin subunit 2 (PFD2, also known as Gim4 in budding yeasts). PFD2 is part of the prefoldin heterohexamer complex (consists of two PFD-alpha type and four PFD-beta type subunits) that binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it [[cite:PUB00015158]]. It binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for non-native proteins [[cite:PUB00008051], [cite:PUB00063296]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006457
Biological process Protein folding The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
Subterm of
GO:0016272
Cellular component Prefoldin complex A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
Subterm of

Associated Lotus transcripts 5

Transcript Name Description Predicted domains Domain count
Lj3g3v0743580.1
– PREDICTED: probable prefoldin subunit 2-like [Glycine max] gi|356517732|ref|XP_003527540.1|
Domains
13
Lj3g3v0743590.1
– PREDICTED: probable prefoldin subunit 2-like [Glycine max] gi|356517732|ref|XP_003527540.1|
Domains
9
LotjaGi3g1v0100900.1
– Prefoldin subunit 2 family protein; TAIR: AT3G22480.1 prefoldin 2; Swiss-Prot: sp|Q9LJ98|PFD2_ARATH Probable prefoldin subunit 2; TrEMBL-Plants: tr|A0A151SJM2|A0A151SJM2_CAJCA Putative prefoldin subunit 2; Found in the gene: LotjaGi3g1v0100900
Domains
9
LotjaGi3g1v0100900.2
– Prefoldin subunit 2 family protein; TAIR: AT3G22480.1 prefoldin 2; Swiss-Prot: sp|Q9LJ98|PFD2_ARATH Probable prefoldin subunit 2; TrEMBL-Plants: tr|A0A151SJM2|A0A151SJM2_CAJCA Putative prefoldin subunit 2; Found in the gene: LotjaGi3g1v0100900
Domains
9
LotjaGi3g1v0100900.3
– Prefoldin subunit 2 family protein; TAIR: AT3G22480.1 prefoldin 2; Swiss-Prot: sp|Q9LJ98|PFD2_ARATH Probable prefoldin subunit 2; TrEMBL-Plants: tr|A0A151SJM2|A0A151SJM2_CAJCA Putative prefoldin subunit 2; Found in the gene: LotjaGi3g1v0100900
Domains
9

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 20.00