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GO:0016272

View this GO term in other databases

Overview

Field Value
Namespace Cellular component
Short description Prefoldin complex
Full defintion A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics.
Subterm of

Relationships

The relationship of GO:0016272 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
GOCjl
PMID
Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ
Cell. 1998 May 29; 93 (5): 863–73.PMID: 9630229

We describe the discovery of a heterohexameric chaperone protein, prefoldin, based on its ability to capture unfolded actin. Prefoldin binds specifically to cytosolic chaperonin (c-cpn) and transfers target proteins to it. Deletion of the gene encoding a prefoldin subunit in S. cerevisiae results in a phenotype similar to those found when c-cpn is mutated, namely impaired functions of the actin and tubulin-based cytoskeleton. Consistent with prefoldin having a general role in chaperonin-mediated folding, we identify homologs in archaea, which have a class II chaperonin but contain neither actin nor tubulin. We show that by directing target proteins to chaperonin, prefoldin promotes folding in an environment in which there are many competing pathways for nonnative proteins.

Associated Lotus transcripts 32

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0106569.1
– PREDICTED: probable prefoldin subunit 4-like [Cicer arietinum] gi|502116842|ref|XP_004495612.1|
GO terms
3
Lj0g3v0357399.1
– PREDICTED: probable prefoldin subunit 3-like [Cicer arietinum] gi|502080358|ref|XP_004486538.1|
GO terms
2
Lj1g3v3608340.1
– PREDICTED: protein UXT homolog isoform X1 [Cicer arietinum] gi|502094018|ref|XP_004490119.1|
GO terms
3
Lj3g3v0743580.1
– PREDICTED: probable prefoldin subunit 2-like [Glycine max] gi|356517732|ref|XP_003527540.1|
GO terms
3
Lj3g3v0743590.1
– PREDICTED: probable prefoldin subunit 2-like [Glycine max] gi|356517732|ref|XP_003527540.1|
GO terms
3
Lj4g3v1389190.1
– Prefoldin subunit [Medicago truncatula] gi|357488567|ref|XP_003614571.1|
GO terms
3
Lj5g3v0817610.1
– Prefoldin subunit [Medicago truncatula] gi|357488567|ref|XP_003614571.1|
GO terms
3
Lj5g3v1412670.1
– PREDICTED: probable prefoldin subunit 4-like [Cicer arietinum] gi|502116842|ref|XP_004495612.1|
GO terms
3
Lj5g3v2258600.1
– PREDICTED: probable prefoldin subunit 5-like [Glycine max] gi|356575420|ref|XP_003555839.1|
GO terms
3
Lj6g3v0935900.1
– PREDICTED: protein UXT homolog isoform X1 [Cicer arietinum] gi|502094018|ref|XP_004490119.1|
GO terms
3
Lj6g3v1315150.3
– PREDICTED: unconventional prefoldin RPB5 interactor-like [Glycine max] gi|356544982|ref|XP_003540925.1|
GO terms
3
Lj6g3v1692480.1
– Prefoldin chaperone subunit family protein [Theobroma cacao] gi|508718436|gb|EOY10333.1|
GO terms
3
LotjaGi1g1v0597300.1
– Prefoldin subunit, putative; TAIR: AT1G26660.1 Prefoldin chaperone subunit family protein; Swiss-Prot: sp|Q54ND3|UXT_DICDI Protein UXT homolog; TrEMBL-Plants: tr|C6SY11|C6SY11_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0597300
GO terms
3
LotjaGi1g1v0597300.2
– Prefoldin subunit, putative; TAIR: AT1G26660.1 Prefoldin chaperone subunit family protein; Swiss-Prot: sp|Q54ND3|UXT_DICDI Protein UXT homolog; TrEMBL-Plants: tr|C6SY11|C6SY11_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0597300
GO terms
3
LotjaGi3g1v0100900.1
– Prefoldin subunit 2 family protein; TAIR: AT3G22480.1 prefoldin 2; Swiss-Prot: sp|Q9LJ98|PFD2_ARATH Probable prefoldin subunit 2; TrEMBL-Plants: tr|A0A151SJM2|A0A151SJM2_CAJCA Putative prefoldin subunit 2; Found in the gene: LotjaGi3g1v0100900
GO terms
3
LotjaGi3g1v0100900.2
– Prefoldin subunit 2 family protein; TAIR: AT3G22480.1 prefoldin 2; Swiss-Prot: sp|Q9LJ98|PFD2_ARATH Probable prefoldin subunit 2; TrEMBL-Plants: tr|A0A151SJM2|A0A151SJM2_CAJCA Putative prefoldin subunit 2; Found in the gene: LotjaGi3g1v0100900
GO terms
3
LotjaGi3g1v0100900.3
– Prefoldin subunit 2 family protein; TAIR: AT3G22480.1 prefoldin 2; Swiss-Prot: sp|Q9LJ98|PFD2_ARATH Probable prefoldin subunit 2; TrEMBL-Plants: tr|A0A151SJM2|A0A151SJM2_CAJCA Putative prefoldin subunit 2; Found in the gene: LotjaGi3g1v0100900
GO terms
3
LotjaGi3g1v0318300.1
– Prefoldin subunit 1; TAIR: AT2G07340.1 PREFOLDIN 1; Swiss-Prot: sp|Q3SZE2|PFD1_BOVIN Prefoldin subunit 1; TrEMBL-Plants: tr|V7AJN3|V7AJN3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0318300
GO terms
3
LotjaGi4g1v0224500.1
– Prefoldin subunit 6; TAIR: AT1G29990.1 prefoldin 6; Swiss-Prot: sp|Q03958|PFD6_MOUSE Prefoldin subunit 6; TrEMBL-Plants: tr|I3SKF9|I3SKF9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0224500
GO terms
3
LotjaGi4g1v0224500.2
– Prefoldin subunit 6; TAIR: AT1G29990.1 prefoldin 6; Swiss-Prot: sp|Q03958|PFD6_MOUSE Prefoldin subunit 6; TrEMBL-Plants: tr|I3SKF9|I3SKF9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0224500
GO terms
3
LotjaGi4g1v0224500.3
– Prefoldin subunit; TAIR: AT1G29990.1 prefoldin 6; Swiss-Prot: sp|Q17Q89|PFD6_BOVIN Prefoldin subunit 6; TrEMBL-Plants: tr|I3SKF9|I3SKF9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0224500
GO terms
3
LotjaGi4g1v0224500.4
– Prefoldin subunit; TAIR: AT1G29990.1 prefoldin 6; Swiss-Prot: sp|Q03958|PFD6_MOUSE Prefoldin subunit 6; TrEMBL-Plants: tr|I3SKF9|I3SKF9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0224500
GO terms
3
LotjaGi5g1v0103000.1
– Prefoldin subunit 6; TAIR: AT1G29990.1 prefoldin 6; Swiss-Prot: sp|Q03958|PFD6_MOUSE Prefoldin subunit 6; TrEMBL-Plants: tr|I3SKF9|I3SKF9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0103000
GO terms
3
LotjaGi5g1v0103000.2
– Prefoldin subunit; TAIR: AT1G29990.1 prefoldin 6; Swiss-Prot: sp|Q17Q89|PFD6_BOVIN Prefoldin subunit 6; TrEMBL-Plants: tr|I3SKF9|I3SKF9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0103000
GO terms
3
LotjaGi5g1v0103000.3
– Prefoldin subunit; TAIR: AT1G29990.1 prefoldin 6; Swiss-Prot: sp|Q17Q89|PFD6_BOVIN Prefoldin subunit 6; TrEMBL-Plants: tr|I3SKF9|I3SKF9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0103000
GO terms
3
LotjaGi5g1v0212100.1
– Prefoldin subunit 4; TAIR: AT1G08780.1 ABI3-interacting protein 3; Swiss-Prot: sp|Q9M4B5|PFD4_ARATH Probable prefoldin subunit 4; TrEMBL-Plants: tr|I3SG24|I3SG24_LOTJA Prefoldin subunit 4; Found in the gene: LotjaGi5g1v0212100
GO terms
3
LotjaGi5g1v0212100.2
– Prefoldin subunit 4; TAIR: AT1G08780.1 ABI3-interacting protein 3; Swiss-Prot: sp|Q9M4B5|PFD4_ARATH Probable prefoldin subunit 4; TrEMBL-Plants: tr|I3SG24|I3SG24_LOTJA Prefoldin subunit 4; Found in the gene: LotjaGi5g1v0212100
GO terms
3
LotjaGi5g1v0352900.1
– Prefoldin subunit, putative; TAIR: AT5G23290.1 prefoldin 5; Swiss-Prot: sp|P57742|PFD5_ARATH Probable prefoldin subunit 5; TrEMBL-Plants: tr|A0A1J7HIW7|A0A1J7HIW7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0352900
GO terms
3
LotjaGi5g1v0352900.2
– Prefoldin subunit, putative; TAIR: AT5G23290.1 prefoldin 5; Swiss-Prot: sp|P57742|PFD5_ARATH Probable prefoldin subunit 5; TrEMBL-Plants: tr|A0A1J7HIW7|A0A1J7HIW7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0352900
GO terms
3
LotjaGi6g1v0183800.1
– Prefoldin subunit, putative; TAIR: AT1G26660.1 Prefoldin chaperone subunit family protein; Swiss-Prot: sp|Q54ND3|UXT_DICDI Protein UXT homolog; TrEMBL-Plants: tr|C6SY11|C6SY11_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi6g1v0183800
GO terms
3
LotjaGi6g1v0183800.2
– Prefoldin subunit, putative; TAIR: AT1G26660.1 Prefoldin chaperone subunit family protein; Swiss-Prot: sp|Q54ND3|UXT_DICDI Protein UXT homolog; TrEMBL-Plants: tr|A0A0R0L2B8|A0A0R0L2B8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0183800
GO terms
3
LotjaGi6g1v0260000.1
– Prefoldin subunit 3; TAIR: AT5G49510.1 prefoldin 3; Swiss-Prot: sp|P57741|PFD3_ARATH Probable prefoldin subunit 3; TrEMBL-Plants: tr|I3SQ31|I3SQ31_LOTJA Prefoldin subunit 3; Found in the gene: LotjaGi6g1v0260000
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0016272
Cellular component Prefoldin complex 1 3.13