Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR027434 is a Homing endonuclease.
<p>Homing endonucleases are rare-cutting enzymes encoded by inteins and introns. They are found inserted within host genes in eukaryotes, bacteria, archaebacteria and viruses [[cite:PUB00064542]]. By making a site-specific double-strand break in the intronless or inteinless alleles, these nucleases create recombinogenic ends which engage in a gene conversion process that duplicates the intron or intein [[cite:PUB00004478], [cite:PUB00006563]]. There are four families of homing endonucleases classified by the conserved sequence motifs LAGLIDADG, GIY-YIG, H-N-H and His-Cys box [[cite:PUB00004478], [cite:PUB00081941]]. Endonucleases of the DOD family contain one or two copies of the 10-residue sequence known as a dodecapeptide or LAGLIDADG motif. LAGLIDADG endonucleases are either monomers, such as I-SceI, that are composed of two pseudo symmetric subdomains, or homodimers, such as I-CreI. In both cases, the LAGLIDADG endonuclease folds into a β-saddle architecture, a common motif for nucleic acid binding proteins [[cite:PUB00050851]].</p> <p>This superfamily represents the homing endonuclease domain.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: pentatricopeptide repeat-containing protein At2g15820-like isoform X1 [Cicer arietinum] gi|502126430|ref|XP_004499305.1| | 13 | ||
| – | Pentatricopeptide repeat-containing protein family; TAIR: AT2G15820.1 endonuclease; Swiss-Prot: sp|Q9XIL5|PP154_ARATH Pentatricopeptide repeat-containing protein At2g15820, chloroplastic; TrEMBL-Plants: tr|A0A072VEK1|A0A072VEK1_MEDTR PPR containing plant-like protein; Found in the gene: LotjaGi2g1v0008500 | 13 | ||
| – | Pentatricopeptide repeat-containing protein family; TAIR: AT2G15820.1 endonuclease; Swiss-Prot: sp|Q9XIL5|PP154_ARATH Pentatricopeptide repeat-containing protein At2g15820, chloroplastic; TrEMBL-Plants: tr|A0A072VEK1|A0A072VEK1_MEDTR PPR containing plant-like protein; Found in the gene: LotjaGi2g1v0008500 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00756 | TIGRFAM | 1 | 33.33 |