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IPR028590 is a tRNA (cytidine(32)/guanosine(34)-2-O)-methyltransferase TRM7.
<p>This entry represents the tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferases, including Trm7 from Saccharomyces cerevisiae. Trm7 methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of tRNA(Phe), tRNA(Trp) and tRNA(Leu(UAA)) [[cite:PUB00054996]]. It requires Trm732 for methylation of the cytidine at position 32 and Rtt10/Trm734 for methylation of the nucleotides at position 34 in substrate tRNAs [[cite:PUB00068806]].</p> <p>This entry also includes FTSJ1 from human. FTSJ1 is a homologue of yeast Trm7 and may play a role in the regulation of translation. Mutations in FTSJ1 cause the mental retardation, X-linked 44 (MRX44), which is a disorder characterised by significantly below average general intellectual functioning associated with impairments in adaptive behaviour and manifested during the developmental period [[cite:PUB00068807]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | TRNA processing | The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. | ||
| Molecular function | TRNA methyltransferase activity | Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Ribosomal RNA large subunit methyltransferase E; TAIR: AT5G01230.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q9UET6|TRM7_HUMAN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; TrEMBL-Plants: tr|I1MEI2|I1MEI2_SOYBN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Found in the gene: LotjaGi6g1v0332700 | 11 | ||
| – | Ribosomal RNA large subunit methyltransferase E; TAIR: AT5G01230.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q9UET6|TRM7_HUMAN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; TrEMBL-Plants: tr|A0A0R0GT40|A0A0R0GT40_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0332700 | 8 | ||
| – | Ribosomal RNA large subunit methyltransferase E; TAIR: AT5G01230.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q9UET6|TRM7_HUMAN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; TrEMBL-Plants: tr|I1MEI2|I1MEI2_SOYBN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Found in the gene: LotjaGi6g1v0332700 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF53335 | SUPERFAMILY | 1 | 33.33 |