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IPR015507

Source: InterPro

Description

IPR015507 is a Ribosomal RNA large subunit methyltransferase E.

<p>The ribosomal RNA large subunit methyltransferase E ([ec:2.1.1]) methylates the 23S rRNA. It specifically methylates the uridine in position 2552 of 23s rRNA in the 50S particle using S-adenosyl-L-methionine as a substrate [[cite:PUB00016804]]. It was previously known as cell division protein FtsJ.</p> <p>This entry represents the ribosomal RNA large subunit methyltransferase E family, which also includes tRNA (uridine-2'-O-)-methyltransferases. This enzyme methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop [[cite:PUB00054996]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0001510
Biological process RNA methylation Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.
Subterm of
GO:0008168
Molecular function Methyltransferase activity Catalysis of the transfer of a methyl group to an acceptor molecule.
Subterm of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj2g3v2599880.1
– PREDICTED: ribosomal RNA large subunit methyltransferase E-like [Cicer arietinum] gi|502096998|ref|XP_004490883.1|
Domains
7
Lj3g3v3360940.1
– PREDICTED: adoMet-dependent rRNA methyltransferase spb1-like [Glycine max] gi|356538763|ref|XP_003537870.1|
Domains
13
LotjaGi3g1v0509400.1
– Ribosomal RNA large subunit methyltransferase E; TAIR: AT4G25730.1 FtsJ-like methyltransferase family protein; Swiss-Prot: sp|Q5BH88|SPB1_EMENI AdoMet-dependent rRNA methyltransferase spb1; TrEMBL-Plants: tr|G7JTV9|G7JTV9_MEDTR Putative rRNA methyltransferase; Found in the gene: LotjaGi3g1v0509400
Domains
17
LotjaGi6g1v0332700.6
– Ribosomal RNA large subunit methyltransferase E; TAIR: AT5G01230.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q9UET6|TRM7_HUMAN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; TrEMBL-Plants: tr|I1MEI2|I1MEI2_SOYBN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Found in the gene: LotjaGi6g1v0332700
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF53335 SUPERFAMILY 1 25.00