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IPR002877 is a Ribosomal RNA methyltransferase, FtsJ domain.
<p>This entry represents FtsJ domain, which is found in proteins that methylate RNA, including Ribosomal RNA large subunit methyltransferase E (formerly known as RrmJ or FtsJ). RrmJ is a well conserved heat shock protein with close homologs in prokaryotes, archaea, and eukaryotes. RrmJ is responsible for methylating 23 S rRNA at position U2552 in the aminoacyl (A)1-site of the ribosome [[cite:PUB00011786], [cite:PUB00100387], [cite:PUB00100386]]. U2552 is one of the five universally conserved A-loop residues and has been shown to be methylated at the ribose 2'-OH group in the majority of organisms investigated so far. This suggests that this modification plays an important role in the A-loop function. RrmJ recognises its methylation target only when the 23 S rRNA is present in 50 S ribosomal subunits. This suggests that the RrmJ-mediated methylation must occur late in the maturation process of the ribosome. This is in contrast to other known 23 S rRNA modifications that occur in earlier maturation steps.</p> <p>The 1.5 A crystal structure of RrmJ in complex with its cofactor S-adenosylmethionine revealed that RrmJ has a methyltransferase fold. The active site of RrmJ appears to be formed by a catalytic triad consisting of two lysine residues and the negatively charged aspartate residue. Another highly conserved glutamate residue that is present in the active site of RrmJ appears to play only a minor role in the methyltransfer reaction in vivo [[cite:PUB00007205]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Methyltransferase activity | Catalysis of the transfer of a methyl group to an acceptor molecule. | ||
| Biological process | Methylation | The process in which a methyl group is covalently attached to a molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: ribosomal RNA large subunit methyltransferase E-like [Cicer arietinum] gi|502096998|ref|XP_004490883.1| | 7 | ||
| – | PREDICTED: adoMet-dependent rRNA methyltransferase spb1-like [Glycine max] gi|356538763|ref|XP_003537870.1| | 13 | ||
| – | Ribosomal RNA large subunit methyltransferase J; TAIR: AT3G25470.1 bacterial hemolysin-like protein; Swiss-Prot: sp|P19672|YQXC_BACSU Putative rRNA methyltransferase YqxC; TrEMBL-Plants: tr|K7KE27|K7KE27_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0076100 | 18 | ||
| – | Ribosomal RNA large subunit methyltransferase E; TAIR: AT4G25730.1 FtsJ-like methyltransferase family protein; Swiss-Prot: sp|Q5BH88|SPB1_EMENI AdoMet-dependent rRNA methyltransferase spb1; TrEMBL-Plants: tr|G7JTV9|G7JTV9_MEDTR Putative rRNA methyltransferase; Found in the gene: LotjaGi3g1v0509400 | 17 | ||
| – | Ribosomal RNA large subunit methyltransferase E; TAIR: AT5G01230.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q9UET6|TRM7_HUMAN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; TrEMBL-Plants: tr|I1MEI2|I1MEI2_SOYBN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Found in the gene: LotjaGi6g1v0332700 | 11 | ||
| – | Ribosomal RNA large subunit methyltransferase E; TAIR: AT5G01230.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q9UET6|TRM7_HUMAN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; TrEMBL-Plants: tr|A0A0R0GT40|A0A0R0GT40_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0332700 | 8 | ||
| – | Ribosomal RNA large subunit methyltransferase E; TAIR: AT5G01230.1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein; Swiss-Prot: sp|Q9UET6|TRM7_HUMAN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; TrEMBL-Plants: tr|I1MEI2|I1MEI2_SOYBN Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Found in the gene: LotjaGi6g1v0332700 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF53335 | SUPERFAMILY | 1 | 14.29 |