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IPR028591

Source: InterPro

Description

IPR028591 is a DIS3-like exonuclease 2.

<p>DIS3-like exonuclease 2 (DIS3L2) is a 3'-5'-exoribonuclease that specifically recognises RNAs polyuridylated at their 3' end and mediates their degradation. It plays an important role in the mRNA degradation pathway alternative to degradation by Xrn1 and the exosome [[cite:PUB00068808], [cite:PUB00068809]]. This entry also includes DIS3L2 plant homologue, SUPPRESSOR OF VARICOSE (SOV) (At1g77680), which functions in cytoplasmic mRNA decay and suppresses Arabidopsis decapping mutant phenotypes [[cite:PUB00068810]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000175
Molecular function 3'-5'-exoribonuclease activity Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
Subterm of
GO:0034427
Biological process Nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj0g3v0327789.1
– PREDICTED: DIS3-like exonuclease 2-like [Glycine max] gi|356550838|ref|XP_003543790.1|
Domains
11
Lj0g3v0327789.2
– PREDICTED: DIS3-like exonuclease 2-like [Glycine max] gi|356550838|ref|XP_003543790.1|
Domains
11
LotjaGi1g1v0154400.1
– DIS3-like exonuclease 2; TAIR: AT1G77680.1 Ribonuclease II/R family protein; Swiss-Prot: sp|P0DM58|DI3L2_ARATH DIS3-like exonuclease 2; TrEMBL-Plants: tr|A0A0R0GK53|A0A0R0GK53_SOYBN DIS3-like exonuclease 2; Found in the gene: LotjaGi1g1v0154400
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33