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IPR028941 is a WHIM2 domain.
<p>This entry represents the WHIM2 domain found in diverse eukaryotic chromatin proteins, such as animal BAZ/WAL and BPTF proteins, plant RLT, and yeast Itc1. This domain contains the D-TOX E motif (also known as the Williams-Beuren syndrome DDT (WSD) motif) that is conserved from yeasts to animals [[cite:PUB00067481], [cite:PUB00069727], [cite:PUB00075496]].</p> <p>WHIM2 domain is a conserved α helical motif that along with the WHIM1 and WHIM3 motifs, and the DDT domain comprise an α helical module found in diverse eukaryotic chromatin proteins [[cite:PUB00067481]]. Based on the Ioc3 structure, this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins [[cite:PUB00067481], [cite:PUB00069727]]. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes [[cite:PUB00069727]]. The acidic residue from the GxD signature of WHIM2 is a major determinant of the interaction between the ISWI and WHIM motifs. The N-terminal portion of the WHIM2 motif also contacts the inter-nucleosomal linker DNA. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA [[cite:PUB00067481]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Nucleosome/chromatin assembly factor group [Medicago truncatula] gi|357520229|ref|XP_003630403.1| | 11 | ||
| – | DDT; Homeodomain-related [Medicago truncatula] gi|124360728|gb|ABN08705.1| | 7 | ||
| – | DDT; Homeodomain-related [Medicago truncatula] gi|124360728|gb|ABN08705.1| | 4 | ||
| – | DDT; Homeodomain-related [Medicago truncatula] gi|124360728|gb|ABN08705.1| | 14 | ||
| – | PREDICTED: DDT domain-containing protein DDB_G0282237-like [Cicer arietinum] gi|502139715|ref|XP_004503869.1| | 14 | ||
| – | Homeodomain-like transcriptional regulator isoform 2 [Theobroma cacao] gi|508701749|gb|EOX93645.1| | 12 | ||
| – | Homeobox protein Hox-C4 [Medicago truncatula] gi|357446737|ref|XP_003593644.1| | 4 | ||
| – | Homeobox protein, putative; TAIR: AT5G44180.1 Homeodomain-like transcriptional regulator; Swiss-Prot: sp|Q9FFH1|RLT2_ARATH Homeobox-DDT domain protein RLT2; TrEMBL-Plants: tr|K7KY04|K7KY04_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0242000 | 22 | ||
| – | Homeobox protein, putative; TAIR: AT1G28420.1 homeobox-1; Swiss-Prot: sp|F4HY56|RLT1_ARATH Homeobox-DDT domain protein RLT1; TrEMBL-Plants: tr|A0A0B2PKP8|A0A0B2PKP8_GLYSO Homeobox protein 10; Found in the gene: LotjaGi4g1v0061500 | 22 | ||
| – | DDT domain-containing; TAIR: AT5G08630.1 DDT domain-containing protein; Swiss-Prot: sp|Q9NRL2|BAZ1A_HUMAN Bromodomain adjacent to zinc finger domain protein 1A; TrEMBL-Plants: tr|G7LFT5|G7LFT5_MEDTR Nucleosome/chromatin assembly factor group protein, putative; Found in the gene: LotjaGi4g1v0415500 | 12 | ||
| – | Homeodomain-like transcriptional regulator; TAIR: AT4G12750.1 Homeodomain-like transcriptional regulator; Swiss-Prot: sp|F4JRF5|RLT3_ARATH Homeobox-DDT domain protein RLT3; TrEMBL-Plants: tr|K7KRT9|K7KRT9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0439900 | 12 | ||
| – | Homeobox protein, putative; TAIR: AT1G28420.1 homeobox-1; Swiss-Prot: sp|F4HY56|RLT1_ARATH Homeobox-DDT domain protein RLT1; TrEMBL-Plants: tr|A0A0L9VFB6|A0A0L9VFB6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0328200 | 22 | ||
| – | Homeobox protein, putative; TAIR: AT1G28420.1 homeobox-1; Swiss-Prot: sp|F4HY56|RLT1_ARATH Homeobox-DDT domain protein RLT1; TrEMBL-Plants: tr|A0A0L9VFB6|A0A0L9VFB6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0328200 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 7.69 |