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IPR029119 is a Adenine DNA glycosylase, C-terminal.
<p>Adenine DNA glycosylase (called MutY in bacteria and hMYH in humans) initiates repair of A-oxoG to C-G by removing the inappropriately paired adenine base from the DNA backbone. MutY belongs to a structural superfamily of proteins (the NUDIX hydrolase superfamily) that hydrolyse a wide range of organic pyrophosphates [[cite:PUB00034750]].</p> <p>Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ for their activity. They are also recognized by a highly conserved 23-residue nudix motif (GX5EX7REUXEEXGU, where U = I, L or V). However, DNA glycosylase does not seem to contain this signature motif. DNA glycosylase consists of 2 domains: the N-terminal domain contains the catalytic properties of the enzyme and the C-terminal domain affects substrate (oxoG) binding and enzymatic turnover. The C-terminal domain is highly similar to MutT, based on secondary structure and topology, despite low sequence identity. MutT sanitizes the nucleotide precursor pool by hydrolyzing oxo-dGTP to oxo-dGMO and inorganic pyrophosphate. The similarity strongly suggests that the two proteins share a common evolutionary origin [[cite:PUB00079705], [cite:PUB00079706], [cite:PUB00016252], [cite:PUB00014091], [cite:PUB00070208], [cite:PUB00079707], [cite:PUB00079708]].</p> <p>This entry represents the C-terminal domain of MutY. Its structure is similar to the NUDIX fold, which is an α/β/α sandwich [[cite:PUB00070208], [cite:PUB00034750]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: A/G-specific adenine DNA glycosylase-like isoform X2 [Cicer arietinum] gi|502157006|ref|XP_004510726.1| | 17 | ||
| – | PREDICTED: A/G-specific adenine DNA glycosylase-like isoform X1 [Cicer arietinum] gi|502157003|ref|XP_004510725.1| | 17 | ||
| – | A/G-specific adenine DNA glycosylase; TAIR: AT4G12740.2 HhH-GPD base excision DNA repair family protein; Swiss-Prot: sp|F4JRF4|MUTYH_ARATH Adenine DNA glycosylase; TrEMBL-Plants: tr|K7MEX7|K7MEX7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0391200 | 13 | ||
| – | A/G-specific adenine DNA glycosylase; TAIR: AT4G12740.2 HhH-GPD base excision DNA repair family protein; Swiss-Prot: sp|F4JRF4|MUTYH_ARATH Adenine DNA glycosylase; TrEMBL-Plants: tr|K7KZX6|K7KZX6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0391200 | 18 | ||
| – | A/G-specific adenine DNA glycosylase; TAIR: AT4G12740.2 HhH-GPD base excision DNA repair family protein; Swiss-Prot: sp|F4JRF4|MUTYH_ARATH Adenine DNA glycosylase; TrEMBL-Plants: tr|A0A0R0J018|A0A0R0J018_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0391200 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |