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IPR003265

Source: InterPro

Description

IPR003265 is a HhH-GPD domain.

<p>The HhH-GPD superfamily gets its name from its hallmark helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate [[cite:PUB00013719], [cite:PUB00074987]]. This domain is found in a diverse range of structurally related DNA repair proteins that include: endonuclease III, [ec:4.2.99.18] and DNA glycosylase MutY, an A/G-specific adenine glycosylase. Both of these enzymes have a C-terminal iron-sulphur cluster loop (FCL). The methyl-CPG binding protein (MBD4) also contain a related domain that is a thymine DNA glycosylase [[cite:PUB00019698]]. The family also includes DNA-3-methyladenine glycosylase II [ec:3.2.2.21], 8-oxoguanine DNA glycosylases and other members of the AlkA family.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0006284
Biological process Base-excision repair In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.
Subterm of

Associated Lotus transcripts 33

Transcript Name Description Predicted domains Domain count
Lj0g3v0121289.1
– DNA glycosylase superfamily protein [Arabidopsis thaliana] gi|42572315|ref|NP_974253.1|
Domains
8
Lj0g3v0134359.1
– PREDICTED: N-glycosylase/DNA lyase OGG1-like isoform X1 [Cicer arietinum] gi|502135915|ref|XP_004502497.1|
Domains
13
Lj0g3v0207679.1
– DNA glycosylase superfamily protein [Arabidopsis thaliana] gi|42572315|ref|NP_974253.1|
Domains
6
Lj0g3v0257719.1
– DNA glycosylase superfamily protein [Arabidopsis thaliana] gi|42572315|ref|NP_974253.1|
Domains
7
Lj1g3v4695520.1
– PREDICTED: protein ROS1-like [Glycine max] gi|356503779|ref|XP_003520681.1|
Domains
13
Lj1g3v4695520.3
– PREDICTED: protein ROS1-like [Glycine max] gi|356503779|ref|XP_003520681.1|
Domains
14
Lj3g3v2389760.1
– PREDICTED: A/G-specific adenine DNA glycosylase-like isoform X1 [Cicer arietinum] gi|502157003|ref|XP_004510725.1|
Domains
12
Lj3g3v2389760.2
– PREDICTED: A/G-specific adenine DNA glycosylase-like isoform X2 [Cicer arietinum] gi|502157006|ref|XP_004510726.1|
Domains
17
Lj3g3v2389760.3
– PREDICTED: A/G-specific adenine DNA glycosylase-like isoform X1 [Cicer arietinum] gi|502157003|ref|XP_004510725.1|
Domains
17
Lj3g3v3302770.1
– PREDICTED: endonuclease III-like protein 1-like [Cicer arietinum] gi|502148937|ref|XP_004507328.1|
Domains
23
Lj4g3v0071130.1
– Uncharacterized protein isoform 1 [Theobroma cacao] gi|508778582|gb|EOY25838.1|
Domains
8
Lj5g3v2298120.1
– PREDICTED: DNA-3-methyladenine glycosylase 1-like isoform X1 [Cicer arietinum] gi|502131517|ref|XP_004501010.1|
Domains
12
LotjaGi1g1v0263300.1
– N-glycosylase/DNA lyase; TAIR: AT1G21710.1 8-oxoguanine-DNA glycosylase 1; Swiss-Prot: sp|Q9FNY7|OGG1_ARATH N-glycosylase/DNA lyase OGG1; TrEMBL-Plants: tr|A0A0S3RDM0|A0A0S3RDM0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0263300
Domains
17
LotjaGi1g1v0419500.1
– DNA-3-methyladenine glycosylase 1; TAIR: AT1G19480.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q92383|MAG1_SCHPO DNA-3-methyladenine glycosylase 1; TrEMBL-Plants: tr|I1JTA6|I1JTA6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0419500
Domains
11
LotjaGi1g1v0679900.1
– DNA glycosylase; TAIR: AT2G36490.1 demeter-like 1; Swiss-Prot: sp|Q9SJQ6|ROS1_ARATH Protein ROS1; TrEMBL-Plants: tr|A0A0B2QF73|A0A0B2QF73_GLYSO Protein ROS1; Found in the gene: LotjaGi1g1v0679900
Domains
18
LotjaGi1g1v0679900.2
– DNA glycosylase; TAIR: AT2G36490.1 demeter-like 1; Swiss-Prot: sp|Q9SJQ6|ROS1_ARATH Protein ROS1; TrEMBL-Plants: tr|A0A0B2QF73|A0A0B2QF73_GLYSO Protein ROS1; Found in the gene: LotjaGi1g1v0679900
Domains
18
LotjaGi1g1v0679900.3
– DNA glycosylase; TAIR: AT2G36490.1 demeter-like 1; Swiss-Prot: sp|Q9SJQ6|ROS1_ARATH Protein ROS1; TrEMBL-Plants: tr|A0A0B2QF73|A0A0B2QF73_GLYSO Protein ROS1; Found in the gene: LotjaGi1g1v0679900
Domains
18
LotjaGi2g1v0026200_LC.1
– Methyl-CpG-binding domain protein 4; TAIR: AT3G07930.3 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q0IGK1|MBD4L_ARATH Methyl-CpG-binding domain protein 4-like protein; TrEMBL-Plants: tr|V4SJG7|V4SJG7_9ROSI Uncharacterized protein; Found in the gene: LotjaGi2g1v0026200_LC
Domains
9
LotjaGi2g1v0026300_LC.1
– Photosystem II CP47 reaction center protein; TAIR: AT3G07930.3 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q0IGK1|MBD4L_ARATH Methyl-CpG-binding domain protein 4-like protein; TrEMBL-Plants: tr|K7LYE7|K7LYE7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0026300_LC
Domains
7
LotjaGi2g1v0026500_LC.3
– Methyl-CpG-binding domain protein 4; TAIR: AT3G07930.3 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q0IGK1|MBD4L_ARATH Methyl-CpG-binding domain protein 4-like protein; TrEMBL-Plants: tr|W9QY11|W9QY11_9ROSA Methyl-CpG-binding domain protein 4; Found in the gene: LotjaGi2g1v0026500_LC
Domains
7
LotjaGi2g1v0026500_LC.4
– Methyl-CpG-binding domain protein 4; TAIR: AT3G07930.3 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q0IGK1|MBD4L_ARATH Methyl-CpG-binding domain protein 4-like protein; TrEMBL-Plants: tr|A0A151SQL7|A0A151SQL7_CAJCA Methyl-CpG-binding domain protein 4; Found in the gene: LotjaGi2g1v0026500_LC
Domains
7
LotjaGi2g1v0156400_LC.34
– Transcriptional activator DEMETER; TAIR: AT3G10010.1 demeter-like 2; Swiss-Prot: sp|Q8LK56|DME_ARATH Transcriptional activator DEMETER; TrEMBL-Plants: tr|A0A0B2NV47|A0A0B2NV47_GLYSO Transcriptional activator DEMETER; Found in the gene: LotjaGi2g1v0156400_LC
Domains
11
LotjaGi2g1v0156400_LC.37
– Transcriptional activator DEMETER; TAIR: AT3G10010.1 demeter-like 2; Swiss-Prot: sp|Q9SR66|DML2_ARATH DEMETER-like protein 2; TrEMBL-Plants: tr|A0A0B2NV47|A0A0B2NV47_GLYSO Transcriptional activator DEMETER; Found in the gene: LotjaGi2g1v0156400_LC
Domains
10
LotjaGi2g1v0156400_LC.6
– Transcriptional activator DEMETER; TAIR: AT3G10010.1 demeter-like 2; Swiss-Prot: sp|Q9SR66|DML2_ARATH DEMETER-like protein 2; TrEMBL-Plants: tr|A0A0B2NV47|A0A0B2NV47_GLYSO Transcriptional activator DEMETER; Found in the gene: LotjaGi2g1v0156400_LC
Domains
11
LotjaGi2g1v0389900.1
– DNA-3-methyladenine glycosylase 1; TAIR: AT1G75230.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|O94468|MAG2_SCHPO Probable DNA-3-methyladenine glycosylase 2; TrEMBL-Plants: tr|G7KDL7|G7KDL7_MEDTR HhH-GPD base excision DNA repair family protein; Found in the gene: LotjaGi2g1v0389900
Domains
11
LotjaGi2g1v0389900.2
– DNA-3-methyladenine glycosylase 1; TAIR: AT1G75230.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|O94468|MAG2_SCHPO Probable DNA-3-methyladenine glycosylase 2; TrEMBL-Plants: tr|G7KDL7|G7KDL7_MEDTR HhH-GPD base excision DNA repair family protein; Found in the gene: LotjaGi2g1v0389900
Domains
11
LotjaGi2g1v0389900.3
– DNA-3-methyladenine glycosylase 1; TAIR: AT1G75230.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|O94468|MAG2_SCHPO Probable DNA-3-methyladenine glycosylase 2; TrEMBL-Plants: tr|G7KDL7|G7KDL7_MEDTR HhH-GPD base excision DNA repair family protein; Found in the gene: LotjaGi2g1v0389900
Domains
11
LotjaGi3g1v0391200.2
– A/G-specific adenine DNA glycosylase; TAIR: AT4G12740.2 HhH-GPD base excision DNA repair family protein; Swiss-Prot: sp|F4JRF4|MUTYH_ARATH Adenine DNA glycosylase; TrEMBL-Plants: tr|K7KZX6|K7KZX6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0391200
Domains
18
LotjaGi3g1v0391200.3
– A/G-specific adenine DNA glycosylase; TAIR: AT4G12740.2 HhH-GPD base excision DNA repair family protein; Swiss-Prot: sp|F4JRF4|MUTYH_ARATH Adenine DNA glycosylase; TrEMBL-Plants: tr|A0A0R0J018|A0A0R0J018_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0391200
Domains
18
LotjaGi3g1v0497800.1
– Endonuclease III homolog; TAIR: AT2G31450.2 DNA glycosylase superfamily protein; Swiss-Prot: sp|Q9SIC4|NTH1_ARATH Endonuclease III homolog 1, chloroplastic; TrEMBL-Plants: tr|A0A0L9V790|A0A0L9V790_PHAAN Endonuclease III homolog; Found in the gene: LotjaGi3g1v0497800
Domains
21
LotjaGi4g1v0237800.1
– DNA glycosylase; TAIR: AT3G47830.1 DNA glycosylase superfamily protein; Swiss-Prot: sp|F4JCQ3|DG783_ARATH Putative DNA glycosylase At3g47830; TrEMBL-Plants: tr|A0A151QT39|A0A151QT39_CAJCA Protein ROS1; Found in the gene: LotjaGi4g1v0237800
Domains
12
LotjaGi5g1v0090900_LC.1
– DNA glycosylase; TAIR: AT2G36490.1 demeter-like 1; Swiss-Prot: sp|Q9SJQ6|ROS1_ARATH Protein ROS1; TrEMBL-Plants: tr|K7LHS4|K7LHS4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0090900_LC
Domains
18
LotjaGi6g1v0277400.1
– DNA glycosylase; TAIR: AT4G26030.1 C2H2-like zinc finger protein; Swiss-Prot: sp|O31544|YFJP_BACSU Putative DNA-3-methyladenine glycosylase YfjP; TrEMBL-Plants: tr|A0A0B2S7Q6|A0A0B2S7Q6_GLYSO Uncharacterized protein; Found in the gene: LotjaGi6g1v0277400
Domains
7

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 3.03