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IPR030373 is a Polyamine biosynthesis domain, conserved site.
<p>The nearly ubiquitous polyamines (putrescine, spermidine and spermine) are polycationic mediators of cell proliferation and differentiation whose functions likely provide both stability and neutralisation for nucleic acids. The following polyamine biosynthetic enzymes are evolutionary related and contain a polyamine biosynthesis (PABS) domain [[cite:PUB00004525]]:</p> <ul> <li>Spermidine synthase ([ec:2.5.1.16]) (putrescine aminopropyltransferase). It catalyses the last step in the biosynthesis of spermidine from arginine and methionine; the conversion of putrescine to spermidine using decarboxylated S-adenosylmethionine as the cofactor.</li> <li>Spermine synthase ([ec:2.5.1.22]) (spermidine aminopropyltransferase). It converts spermidine into spermine using decarboxylated S-adenosylmethionine as the cofactor.</li> <li>Putrescine N-methyltransferase ([ec:2.1.1.53]). It catalyses a step in the biosynthesis of nicotine in plants; the methylation of putrescine to N-methylputrescine using S-adenosylmethionine as the cofactor.</li> </ul> <p>This conserved site consists of a glycine-rich conserved region in the PABS domain.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: NADH dehydrogenase [ubiquinone] gi|225437963|ref|XP_002271401.1| | 14 | ||
| – | Spermidine synthase [Ammopiptanthus mongolicus] gi|99083515|gb|ABF66657.1| | 15 | ||
| – | Spermidine synthase [Ammopiptanthus mongolicus] gi|99083515|gb|ABF66657.1| | 13 | ||
| – | Spermine synthase [Lotus japonicus] gi|126153733|emb|CAM35498.1| | 11 | ||
| – | Spermine synthase [Lotus japonicus] gi|126153733|emb|CAM35498.1| | 14 | ||
| – | Spermidine synthase [Lotus japonicus] gi|126153731|emb|CAM35497.1| | 18 | ||
| – | Spermidine synthase; TAIR: AT5G53120.1 spermidine synthase 3; Swiss-Prot: sp|Q94BN2|SPSY_ARATH Spermine synthase; TrEMBL-Plants: tr|A2VC29|A2VC29_LOTJA Spermine synthase; Found in the gene: LotjaGi1g1v0282100 | 18 | ||
| – | Spermidine synthase; TAIR: AT5G53120.1 spermidine synthase 3; Swiss-Prot: sp|Q94BN2|SPSY_ARATH Spermine synthase; TrEMBL-Plants: tr|A2VC29|A2VC29_LOTJA Spermine synthase; Found in the gene: LotjaGi1g1v0282100 | 20 | ||
| – | Spermidine synthase; TAIR: AT5G53120.1 spermidine synthase 3; Swiss-Prot: sp|Q94BN2|SPSY_ARATH Spermine synthase; TrEMBL-Plants: tr|A2VC29|A2VC29_LOTJA Spermine synthase; Found in the gene: LotjaGi1g1v0282100 | 18 | ||
| – | Spermidine synthase; TAIR: AT5G53120.1 spermidine synthase 3; Swiss-Prot: sp|Q94BN2|SPSY_ARATH Spermine synthase; TrEMBL-Plants: tr|A2VC29|A2VC29_LOTJA Spermine synthase; Found in the gene: LotjaGi1g1v0282100 | 18 | ||
| – | Spermidine synthase; TAIR: AT1G23820.1 spermidine synthase; Swiss-Prot: sp|Q9ZTR1|SPD1_PEA Spermidine synthase 1; TrEMBL-Plants: tr|A2VC28|A2VC28_LOTJA Spermidine synthase; Found in the gene: LotjaGi2g1v0319700 | 21 | ||
| – | Spermidine synthase; TAIR: AT1G23820.1 spermidine synthase; Swiss-Prot: sp|Q9ZTR0|SPD2_PEA Spermidine synthase 2; TrEMBL-Plants: tr|A0A151SJ65|A0A151SJ65_CAJCA Spermidine synthase 2; Found in the gene: LotjaGi4g1v0164700 | 21 | ||
| – | Spermidine synthase; TAIR: AT1G23820.1 spermidine synthase; Swiss-Prot: sp|Q96557|SPD2_DATST Spermidine synthase 2; TrEMBL-Plants: tr|K7MKR2|K7MKR2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0236200 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02440 | CDD | 1 | 7.69 |