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IPR030394 is a HflX-type guanine nucleotide-binding (G) domain.
<p>This entry represents the HflX-type G domain.</p> <p>The P-loop guanosine triphosphatases (GTPases) control a multitude of biological processes, ranging from cell division, cell cycling, and signal transduction, to ribosome assembly and protein synthesis. GTPases exert their control by interchanging between an inactive GDP-bound state and an active GTP-bound state, thereby acting as molecular switches. The common denominator of GTPases is the highly conserved guanine nucleotide-binding (G) domain that is responsible for binding and hydrolysis of guanine nucleotides [[cite:PUB00013952], [cite:PUB00056841], [cite:PUB00056762]].</p> <p>Within the translation factor-related (TRAFAC) class of P-loop GTPases, the HflX-type is a widely distributed family of GTPases that interact with the large ribosomal subunit. The broad phylogenetic distribution pattern of HflX GTPases in Bacteria, Archaea, and Eukaryotes (including human) suggests a basic cellular function for this protein family.</p> <p>The HflX-type G domain is composed of six β-strands and five α-helices [[cite:PUB00056841]]. It consists of the following conserved sequence motifs: the G1 motif (or P-loop), consensus GX4GK(S/T), which is responsible for interacting with the alpha and beta-phosphates of nucleotide di- and triphosphates; the G2 variable effector loop (DXnT); the G3 motif (DX2G), which interacts with the gamma-phosphate of nucleotide triphosphates; and the G4 motif (NKXD), which conveys specificity for guanine nucleotides through hydrogen bonding to the base [[cite:PUB00056762]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: GTPase HflX-like [Glycine max] gi|356564314|ref|XP_003550400.1| | 18 | ||
| – | PREDICTED: GTP-binding protein At3g49725, chloroplastic-like [Cicer arietinum] gi|502098523|ref|XP_004491256.1| | 21 | ||
| – | PREDICTED: GTPase HflX-like [Glycine max] gi|356564314|ref|XP_003550400.1| | 22 | ||
| – | GTPase obg; TAIR: AT3G49725.1 GTP-binding protein, HflX; Swiss-Prot: sp|Q0WTB4|Y3725_ARATH GTP-binding protein At3g49725, chloroplastic; TrEMBL-Plants: tr|K7KB86|K7KB86_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0048900 | 20 | ||
| – | GTPase obg; TAIR: AT5G57960.1 GTP-binding protein, HflX; Swiss-Prot: sp|P25519|HFLX_ECOLI GTPase HflX; TrEMBL-Plants: tr|A0A0S3RQD2|A0A0S3RQD2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0011800 | 24 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 20.00 |