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IPR030667 is a NEDD8-activating enzyme E1 regulatory subunit APP-BP1.
<p>APP-BP1 (beta-Amyloid precursor protein binding protein 1), also known as Ula1 in yeasts, is a regulatory subunit of the E1 enzyme. Human APP-BP1 is necessary for cell cycle progression through the S-M checkpoint [[cite:PUB00073566]]. Drosophila APP-BP1 interacts antagonistically with APPL (APP-like protein) during Drosophila development [[cite:PUB00073567]].</p> <p>Ubiquitin-like proteins (ublps) are conjugated to their targets by the sequential action of E1, E2 and often E3 enzymes. Each Ublp has a dedicated E1, or activating enzyme, that initiates its conjugation cascade. In humans the NEDD8 activating E1 enzyme is a heterodimer composed of APP-BP1 and UBA3 subunits. The ubiquitin-like protein (Ublp) NEDD8 regulates cell division, signalling and embryogenesis [[cite:PUB00032681]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | NEDD8 activating enzyme activity | Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade. | ||
| Biological process | Protein neddylation | Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: NEDD8-activating enzyme E1 regulatory subunit-like [Glycine max] gi|356517638|ref|XP_003527494.1| | 9 | ||
| – | NEDD8-activating enzyme E1 regulatory subunit; TAIR: AT1G05180.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|P42744|AXR1_ARATH NEDD8-activating enzyme E1 regulatory subunit AXR1; TrEMBL-Plants: tr|I3SW23|I3SW23_LOTJA NEDD8-activating enzyme E1 regulatory subunit; Found in the gene: LotjaGi3g1v0466500 | 10 | ||
| – | NEDD8-activating enzyme E1 regulatory subunit; TAIR: AT1G05180.1 NAD(P)-binding Rossmann-fold superfamily protein; Swiss-Prot: sp|P42744|AXR1_ARATH NEDD8-activating enzyme E1 regulatory subunit AXR1; TrEMBL-Plants: tr|I3SW23|I3SW23_LOTJA NEDD8-activating enzyme E1 regulatory subunit; Found in the gene: LotjaGi3g1v0466500 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd01493 | CDD | 1 | 33.33 |