Description

IPR031166 is a EngA-type guanine nucleotide-binding (G) domain.

<p>The P-loop guanosine triphosphatases (GTPases) control a multitude of biological processes, ranging from cell division, cell cycling, and signal transduction, to ribosome assembly and protein synthesis. GTPases exert their control by interchanging between an inactive GDP-bound state and an active GTP-bound state, thereby acting as molecular switches. The common denominator of GTPases is the highly conserved guanine nucleotide-binding (G) domain that is responsible for binding and hydrolysis of guanine nucleotides.</p> <p>EngA (Essential neisserial GTPase A) proteins belong to TrmE-Era-EngA-YihA- Septin like superfamily of TRAFAC class and form a unique family of bacterial GTPases with two G domains in tandem, namely GD1 and GD2, followed by a C- terminal KH-like domain. They have been shown to interact with the bacterial ribosome and to be involved in its biogenesis [[cite:PUB00013952], [cite:PUB00074838], [cite:PUB00041422], [cite:PUB00074839], [cite:PUB00065763]].</p> <p>The EngA-type G domains consist of ~159-170 amino acid residues and show sequence homology to the Era-type G domain. The EngA-type G domain has thus also been termed Der, because it has double Era-like G domains [[cite:PUB00074838]]. The EngA- type G domain is composed of 5 α helices and 6 β sheets linked by characteristic loops constituting switch I and II. Each EngA- type G domain contains conserved residues organised in five distinct motifs numbered G1-G5. In the G1/Walker A motifs of EngA (Gx(4)GKS) or P-loop, the two invariant lysine residues are known to coordinate the phosphate of nucleotide. G2 (DxxG) belongs to the loop forming switch I and interacts with a Mg(2+) ion as well as the G3/Walker B motif (DxxG). G4 has a characteristic NKxD sequence that is unique to GTPases and provides specificity to GTP. The G5 motif (SA) is less obvious.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 3

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: