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IPR032570

Source: InterPro

Description

IPR032570 is a Splicing factor 1, helix-hairpin domain.

<p>This helix-hairpin domain can be found in the N-terminal region of mammalian splicing factor 1 (SF1), plant splicing factor-like protein 1 and fungal branchpoint binding proteins (BBP) [[cite:PUB00074691]]. These proteins are required for pre-spliceosome formation, which is the first step of pre-mRNA splicing [[cite:PUB00074790], [cite:PUB00074791], [cite:PUB00101802]].</p> <p>SF1 forms a complex with U2AF65 through the interaction between this domain and the C-terminal U2AF homology motif domain (UHM) of U2AF65. This domain forms a secondary, hydrophobic interface with U2AF65 (UHM) to lock the orientation of the two subunits, which is essential for cooperative formation of the ternary SF1-U2AF65-RNA complex [[cite:PUB00063947]]. This domain contains a highly conserved SPSP motif at its C terminus; the phosphorylation of the SPSP motif induces a disorder-to-order transition within a novel SF1/U2AF65 interface [[cite:PUB00064036]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
Lj3g3v3725550.1
– PREDICTED: branchpoint-bridging protein-like isoform X1 [Cicer arietinum] gi|502169018|ref|XP_004514517.1|
Domains
27
LotjaGi3g1v0552600.1
– RNA-binding protein 3; TAIR: AT5G51300.1 splicing factor-like protein; Swiss-Prot: sp|P0CO45|BBP_CRYNB Branchpoint-bridging protein; TrEMBL-Plants: tr|I1L5P7|I1L5P7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0552600
Domains
30

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00