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IPR033031 is a Scc2/Nipped-B family.
<p>This entry represents the Nipped-B protein and its homologues, including Mis4 from fission yeast, Scc2 from budding yeast and Nipbl from zebrafish and Nipped-B from Drosophila.</p> <p>Budding yeast Scc2 is known to be part of the loader for the cohesion to be loaded onto the chromosome [[cite:PUB00079283]]. It has also been shown to regulate gene expression independent of cohesin [[cite:PUB00079284]].</p> <p>Drosophila melanogaster Nipped-B protein is a chromatin binding protein that is involved in sister chromatid cohesion. Nipped-B and its Mau-2 partner are required for cohesin to associate with chromosomes [[cite:PUB00077486]]. The Drosophila Nipped-B has also been shown to regulate gene expression [[cite:PUB00077484]].</p> <p>The zebrafish Nipbl has also been shown to regulate transcription. Nipbl has the ability to interact with other molecules such as histone deacetylases, HP-1gamma, and chromatin remodelling factors. It has been suggested that Nipbl is a cohesin-asociated scaffold protein that have functions other than loading cohesin [[cite:PUB00079285]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Chromatin binding | Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. | ||
| Biological process | Regulation of gene expression | Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Phospholipase-like protein (PEARLI 4) family [Arabidopsis thaliana] gi|18398247|ref|NP_565397.1| | 7 | ||
| – | Phospholipase-like protein (PEARLI 4) family [Arabidopsis thaliana] gi|18398247|ref|NP_565397.1| | 7 | ||
| – | Phospholipase-like (PEARLI 4) family protein [Arabidopsis thaliana] gi|145334227|ref|NP_001078494.1| | 7 | ||
| – | PREDICTED: nipped-B-like protein-like [Cicer arietinum] gi|502091147|ref|XP_004489457.1| | 11 | ||
| – | PREDICTED: nipped-B-like protein-like [Cicer arietinum] gi|502091147|ref|XP_004489457.1| | 7 | ||
| – | At2g16900/F12A24.8 [Arabidopsis lyrata subsp]. lyrata] gi|297836406|ref|XP_002886085.1| | 7 | ||
| – | Phospholipase-like (PEARLI 4) family protein [Arabidopsis thaliana] gi|15236270|ref|NP_195237.1| | 7 | ||
| – | Nipped-B-like protein; TAIR: AT5G15540.1 PHD finger family protein; Swiss-Prot: sp|F5HSE3|NIPLA_DANRE Nipped-B-like protein A; TrEMBL-Plants: tr|K7LXL8|K7LXL8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0265500 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 12.50 |