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IPR033113 is a Phospholipase A2, histidine active site.
<p>Phospholipase A2 ([ec:3.1.1.4]) (PLA2) is a small lipolytic enzyme that releases fatty acids from the second carbon group of glycerol. It is involved in a number of physiologically important cellular processes, such as the liberation of arachidonic acid from membrane phospholipids [[cite:PUB00003922]]. It plays a pivotal role in the biosynthesis of prostaglandin and other mediators of inflammation. PLA2 has four to seven disulphide bonds and binds a calcium ion that is essential for activity. Within the active enzyme, the alpha amino group is involved in a conserved hydrogen-bonding network linking the N-terminal region to the active site. The side chains of two conserved residues, His and Asp, participate in the catalytic network [[cite:PUB00001378]].</p> <p>Many PLA2's are widely distributed in snakes, lizards, bees and mammals. In mammals there are at least four forms: pancreatic, membrane-associated as well as two less well characterised forms. The venom of most snakes contains multiple forms of PLA2. Some of them are presynaptic neurotoxins which inhibit neuromuscular transmission by blocking acetylcholine release from the nerve termini.</p> <p>This entry represents the PLA2 active site histidine and contains three cysteines involved in disulfide bonds.</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: phospholipase A2-alpha-like [Cicer arietinum] gi|502164275|ref|XP_004513106.1| | 13 | ||
– | PREDICTED: phospholipase A2-alpha-like [Cicer arietinum] gi|502164275|ref|XP_004513106.1| | 16 | ||
– | PREDICTED: phospholipase A2-alpha-like [Cicer arietinum] gi|502164275|ref|XP_004513106.1| | 13 | ||
– | Phospholipase A2 family protein; TAIR: AT4G29460.1 Phospholipase A2 family protein; Swiss-Prot: sp|Q9M0D7|PLA2C_ARATH Phospholipase A2-gamma; TrEMBL-Plants: tr|G7KJ78|G7KJ78_MEDTR Phospholipase A2 family protein; Found in the gene: LotjaGi2g1v0230700 | 16 | ||
– | Phospholipase A2 family protein; TAIR: AT2G06925.1 Phospholipase A2 family protein; Swiss-Prot: sp|Q8S8N6|PLA2A_ARATH Phospholipase A2-alpha; TrEMBL-Plants: tr|K7K119|K7K119_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0233800 | 13 | ||
– | Phospholipase A2 family protein; TAIR: AT2G06925.1 Phospholipase A2 family protein; Swiss-Prot: sp|Q8S8N6|PLA2A_ARATH Phospholipase A2-alpha; TrEMBL-Plants: tr|C6TN49|C6TN49_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0440600 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd04706 | CDD | 1 | 16.67 |