Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR036444 is a Phospholipase A2 domain superfamily.
<p>Proteins containing this domain superfamily include eukaryotic and prokaryotic phospholipase A2 enzymes (PLA2; [ec:3.1.1.4]), small lipolytic enzymes that releases fatty acids from the second carbon group of glycerol, usually in a metal-dependent reaction, to generate lysophospholipid (LysoPL) and a free fatty acid (FA) [[cite:PUB00081579]]. The resulting products are either dietary or used in synthetic pathways for leukotrienes and prostaglandins. Often, arachidonic acid is released as a free fatty acid and acts as second messenger in signaling networks [[cite:PUB00081586]]. These enzymes enable the of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides. In eukaryotes, PLA2 plays a pivotal role in the biosynthesis of prostaglandin and other mediators of inflammation. These enzymes are either secreted or cytosolic; the latter are either Ca dependent or Ca independent. Secreted PLA2s have also been found to specifically bind to a variety of soluble and membrane proteins in mammals, including receptors [[cite:PUB00081580]]. As a toxin, PLA2 is a potent presynaptic neurotoxin which blocks nerve terminals by binding to the nerve membrane and hydrolyzing stable membrane lipids [[cite:PUB00081581]]. The products of the hydrolysis (LysoPL and FA) cannot form bilayers leading to a change in membrane conformation and ultimately to a block in the release of neurotransmitters [[cite:PUB00081623], [cite:PUB00081624], [cite:PUB00081625]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Phospholipase A2 activity | Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. | ||
| Biological process | Phospholipid metabolic process | The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester. | ||
| Biological process | Arachidonic acid secretion | The controlled release of arachidonic acid from a cell or a tissue. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Phospholipase A2 family protein; TAIR: AT4G29460.1 Phospholipase A2 family protein; Swiss-Prot: sp|Q9M0D7|PLA2C_ARATH Phospholipase A2-gamma; TrEMBL-Plants: tr|G7KJ78|G7KJ78_MEDTR Phospholipase A2 family protein; Found in the gene: LotjaGi2g1v0230700 | 16 | ||
| – | Phospholipase A2 family protein; TAIR: AT2G06925.1 Phospholipase A2 family protein; Swiss-Prot: sp|Q8S8N6|PLA2A_ARATH Phospholipase A2-alpha; TrEMBL-Plants: tr|K7K119|K7K119_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0233800 | 13 | ||
| – | Phospholipase A2 family protein; TAIR: AT2G06925.1 Phospholipase A2 family protein; Swiss-Prot: sp|Q8S8N6|PLA2A_ARATH Phospholipase A2-alpha; TrEMBL-Plants: tr|C6TN49|C6TN49_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0440600 | 16 | ||
| – | Phospholipase A2; TAIR: AT4G29070.1 Phospholipase A2 family protein; Swiss-Prot: sp|Q9XG81|PLA22_ORYSJ Probable phospholipase A2 homolog 2; TrEMBL-Plants: tr|A0A072THL8|A0A072THL8_MEDTR Phospholipase A2; Found in the gene: LotjaGi6g1v0179000 | 4 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF48619 | SUPERFAMILY | 1 | 25.00 |