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IPR033205 is a COP9 signalosome, subunit CSN8.
<p>The COP9 signalosome (CSN) is a conserved protein complex that regulates the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes [[cite:PUB00078142]], which leads to a decrease in Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 [[cite:PUB00087569]]. Protein kinases CK2 and D, which phosphorylate proteins such as cJun and p53 resulting in their degradation by the ubiquitin-26S proteasome system, also binds to CSN [[cite:PUB00087570], [cite:PUB00087571]]. The mammalian CSN typically consistis of eight subunits designated CSN1-CSN8. The fission yeast possesses a smaller version of the CSN, consisting only of six subunits, whereas a more distant CSN-like complex has been described in Saccharomyces cerevisiae [[cite:PUB00088094]].</p> <p>In the complex, CSN8, which is the smallest subunit, probably interacts directly with CSN3, CSN4 and CSN7 (CSN7A or CSN7B). It is necessary for assembly of the complex [[cite:PUB00078145]]. CSN8 plays an important role in maintaining the proper duration of the G1 phase of the cell cycle [[cite:PUB00078144]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein deneddylation | The removal of a ubiquitin-like protein of the NEDD8 type from a protein. | ||
| Cellular component | COP9 signalosome | A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome. | ||
| Biological process | COP9 signalosome assembly | The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: COP9 signalosome complex subunit 8 [Vitis vinifera] gi|225447785|ref|XP_002266060.1| | 2 | ||
| – | PREDICTED: COP9 signalosome complex subunit 8 [Vitis vinifera] gi|225447785|ref|XP_002266060.1| | 2 | ||
| – | PREDICTED: COP9 signalosome complex subunit 8-like isoform X1 [Cicer arietinum] gi|502077005|ref|XP_004485521.1| | 4 | ||
| – | COP9 signalosome complex subunit 8; TAIR: AT4G14110.1 COP9 signalosome, subunit CSN8; Swiss-Prot: sp|P43255|CSN8_ARATH COP9 signalosome complex subunit 8; TrEMBL-Plants: tr|I3SY35|I3SY35_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0357400 | 7 | ||
| – | COP9 signalosome complex subunit 8; TAIR: AT4G14110.1 COP9 signalosome, subunit CSN8; Swiss-Prot: sp|P43255|CSN8_ARATH COP9 signalosome complex subunit 8; TrEMBL-Plants: tr|I3SY35|I3SY35_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0357400 | 4 | ||
| – | COP9 signalosome complex subunit 8; TAIR: AT4G14110.1 COP9 signalosome, subunit CSN8; Swiss-Prot: sp|P43255|CSN8_ARATH COP9 signalosome complex subunit 8; TrEMBL-Plants: tr|I3SY35|I3SY35_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0357400 | 7 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR13339 | PANTHER | 1 | 16.67 |