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IPR033312

Source: InterPro

Description

IPR033312 is a DNA damage-binding protein 2.

<p>DNA damage-binding protein 2 (DDB2) is required for DNA repair. It binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair [[cite:PUB00078399]]. It is also involved in the initiation of nucleotide excision repair via an ubiquitin ligase complex together with DDB1 and CUL4A (cullin 4A) [[cite:PUB00078400]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003684
Molecular function Damaged DNA binding Interacting selectively and non-covalently with damaged DNA.
Subterm of
GO:0005634
Cellular component Nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
Subterm of
GO:0006281
Biological process DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
Subterm of
GO:0080008
Cellular component Cul4-RING E3 ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
Lj2g3v2256250.1
– DAMAGED DNA-BINDING protein [Medicago truncatula] gi|357490691|ref|XP_003615633.1|
Domains
17
Lj2g3v2256250.2
– DAMAGED DNA-BINDING protein [Medicago truncatula] gi|357490691|ref|XP_003615633.1|
Domains
13
LotjaGi1g1v0121000.1
– Protein DAMAGED DNA-BINDING 2; TAIR: AT5G58760.1 damaged DNA binding 2; Swiss-Prot: sp|Q6NQ88|DDB2_ARATH Protein DAMAGED DNA-BINDING 2; TrEMBL-Plants: tr|I1MBA5|I1MBA5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0121000
Domains
16

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 33.33