Description

IPR034653 is a SPF45, RNA recognition motif.

<p>This entry represents the RNA recognition motif (RRM) of SPF45. This domain is also found in DNA-damage-repair/toleration protein 111.</p> <p>SPF45, also termed RNA-binding motif protein 17 (RBM17), is an RNA-binding protein consisting of an unstructured N-terminal region, followed by a G-patch motif and a C-terminal U2AF (U2 auxiliary factor) homology motifs (UHM) that harbours a RNA recognition motif (RRM) and an Arg-Xaa-Phe sequence motif. SPF45 is a bifunctional protein that functions in splicing and DNA repair. It is involved in regulating alternative splicing of the apoptosis regulatory gene FAS (also called CD95). Its UHM binds UHM-ligand motifs (ULMs) present in the 3' splice site-recognizing factors U2AF65, SF1 and SF3b155 [[cite:PUB00048661]]. It binds to the Holliday junction, which is a key DNA intermediate in the homologous-recombination pathway [[cite:PUB00083867], [cite:PUB00083866]].</p> <p>DNA-damage-repair/toleration protein 111 is a component of the SWAP1-SFPS-RRC1 splicing factor complex which modulates photomorphogenesis by regulating the gene expression and pre-messenger RNA (mRNA) alternative splicing of a large number of genes [[cite:PUB00090466], [cite:PUB00155470], [cite:PUB00155471], [cite:PUB00155472]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 1

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: