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IPR040052

Source: InterPro

Description

IPR040052 is a Splicing factor 45.

<p>This entry includes proteins with a G-patch domain and a RNA recognition motif domain, including mammalian splicing factor 45 (SPF45; also known as RNA-binding motif protein 17 or RBM17) and plant DNA-damage-repair/toleration protein DRT111 (also known as RSN2). SPF45 is an mRNA spliceosomal protein that is required for alternative splicing and the utilization of cryptic splice sites. The beta-110 mutation in the haemoglobin beta causes activation of a cryptic 3' splice site that is the cause of human beta-thalassemia (sickle-cell anemia) [[cite:PUB00090465]]. DRT111 is also required for pre-mRNA splicing, particularly the mRNA for receptor-like kinase SNC4, which activates the defence response to microbial pathogens in plants [[cite:PUB00090466]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0043484
Biological process Regulation of RNA splicing Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
Subterm of
Regulates

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi4g1v0086400.1
– Splicing factor; TAIR: AT1G30480.1 D111/G-patch domain-containing protein; Swiss-Prot: sp|P42698|DR111_ARATH DNA-damage-repair/toleration protein DRT111, chloroplastic; TrEMBL-Plants: tr|V7CI72|V7CI72_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0086400
Domains
19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00