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IPR035309

Source: InterPro

Description

IPR035309 is a Proteasome activator complex subunit 4.

<p>This entry represents proteasome activator complex subunit 4 (gene name PSME4, PA2000 or BLM10), which is particularly associated with the spermatoproteasome. PSME4 binds acetylated histones which are degraded by the proteasome during spermatogenesis. Histones are bound via the bromodomain-like region. PSME4 also activates the proteasome, permitting entry of substrate into the internal chamber where degradation occurs [[cite:PUB00085319]]. PSME4 is also required for the degradation of histones during the DNA damage response in somatic cells [[cite:PUB00085319]]. The structure of the yeast BLM10/proteasome complex has been solved, and shows that BLM10 forms a dome structure over the proteasome entry pore, restricting access for potential substrates and inducing a disordered gate structure [[cite:PUB00076285]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016504
Molecular function Peptidase activator activity Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
Subterm of
GO:0070577
Molecular function Lysine-acetylated histone binding Interacting selectively and non-covalently with a histone in which a lysine residue has been modified by acetylation.
Subterm of
GO:0070628
Molecular function Proteasome binding Interacting selectively and non-covalently with a proteasome, a large multisubunit protein complex that catalyzes protein degradation.
Subterm of

Associated Lotus transcripts 3

Transcript Name Description Predicted domains Domain count
LotjaGi6g1v0136800.1
– Proteasome activator subunit 4; TAIR: AT3G13330.1 proteasome activating protein 200; Swiss-Prot: sp|F4JC97|PSME4_ARATH Proteasome activator subunit 4; TrEMBL-Plants: tr|I1N058|I1N058_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0136800
Domains
7
LotjaGi6g1v0136800.2
– Proteasome activator subunit 4; TAIR: AT3G13330.1 proteasome activating protein 200; Swiss-Prot: sp|F4JC97|PSME4_ARATH Proteasome activator subunit 4; TrEMBL-Plants: tr|I1N058|I1N058_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0136800
Domains
11
LotjaGi6g1v0136800.3
– Proteasome activator subunit 4; TAIR: AT3G13330.1 proteasome activating protein 200; Swiss-Prot: sp|F4JC97|PSME4_ARATH Proteasome activator subunit 4; TrEMBL-Plants: tr|I1N058|I1N058_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0136800
Domains
11

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SignalP-noTM SignalP_GRAM_NEGATIVE 1 33.33