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IPR035773

Source: InterPro

Description

IPR035773 is a Ring finger protein 123, SPRY domain.

<p>This SPRY domain is found at the N terminus of RING finger protein 123 (also known as E3 ubiquitin-protein ligase RNF123, KPC1). The ring finger domain motif is present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. RNF123 displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor p27 (Kip1) [[cite:PUB00086162]] and p105 and inhibits tumor growth via regulation of p50-dependent tumor suppressor genes [[cite:PUB00086163]].</p> <p>Proteins containing this domain also include AtKPC1 from Arabidopsis. AtKPC1 is an E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of KRP1 and KRP2 [[cite:PUB00086397], [cite:PUB00086396]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0311400.2
– E3 ubiquitin-protein ligase RKP; TAIR: AT2G22010.1 related to KPC1; Swiss-Prot: sp|Q9SIZ8|RKP_ARATH E3 ubiquitin-protein ligase RKP; TrEMBL-Plants: tr|I1KBB2|I1KBB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0311400
Domains
24
LotjaGi1g1v0311400.3
– E3 ubiquitin-protein ligase RKP; TAIR: AT2G22010.1 related to KPC1; Swiss-Prot: sp|Q9SIZ8|RKP_ARATH E3 ubiquitin-protein ligase RKP; TrEMBL-Plants: tr|I1KBB2|I1KBB2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0311400
Domains
24

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd16541 CDD 1 50.00