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IPR035940 is a CAP superfamily.
<p>The cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins (CAP) superfamily proteins are found in a wide range of organisms, including prokaryotes [[cite:PUB00016669]] and non-vertebrate eukaryotes [[cite:PUB00020314]], The nine subfamilies of the mammalian CAP superfamily include: the human glioma pathogenesis-related 1 (GLIPR1), Golgi associated pathogenesis related-1 (GAPR1) proteins, peptidase inhibitor 15 (PI15), peptidase inhibitor 16 (PI16), cysteine-rich secretory proteins (CRISPs), CRISP LCCL domain containing 1 (CRISPLD1), CRISP LCCL domain containing 2 (CRISPLD2), mannose receptor like and the R3H domain containing like proteins. Members are most often secreted and have an extracellular endocrine or paracrine function and are involved in processes including the regulation of extracellular matrix and branching morphogenesis, potentially as either proteases or protease inhibitors; in ion channel regulation in fertility; as tumour suppressor or pro-oncogenic genes in tissues including the prostate; and in cell-cell adhesion during fertilisation. The overall protein structural conservation within the CAP superfamily results in fundamentally similar functions for the CAP domain in all members, yet the diversity outside of this core region dramatically alters the target specificity and, thus, the biological consequences [[cite:PUB00054006]]. The Ca2-chelating function [[cite:PUB00020314]] would fit with the various signalling processes (e.g. the CRISP proteins) that members of this family are involved in, and also the sequence and structural evidence of a conserved pocket containing two histidines and a glutamate. It also may explain how [swissprot:Q91055] blocks the Ca2 transporting ryanodine receptors.</p> <p>The CAP domain forms a unique 3 layer α-β-α fold with some, though not all, of the structural elements found in proteases [[cite:PUB00054006]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Pathogenesis-related protein 1; TAIR: AT5G66590.1 CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein; Swiss-Prot: sp|Q41495|ST14_SOLTU STS14 protein; TrEMBL-Plants: tr|I1J911|I1J911_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0396000 | 18 | ||
| – | Cysteine-rich venom protein 1; TAIR: AT5G66590.1 CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein; Swiss-Prot: sp|Q41495|ST14_SOLTU STS14 protein; TrEMBL-Plants: tr|G7KAR2|G7KAR2_MEDTR CAP, cysteine-rich secretory protein, antigen 5; Found in the gene: LotjaGi2g1v0396100 | 18 | ||
| – | Pathogenesis-related protein 1; TAIR: AT5G66590.1 CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein; Swiss-Prot: sp|Q41495|ST14_SOLTU STS14 protein; TrEMBL-Plants: tr|A0A0L9T4T4|A0A0L9T4T4_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0113400 | 18 | ||
| – | Pathogenesis-related protein 1; TAIR: AT4G25780.1 CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein; Swiss-Prot: sp|Q40374|PR1_MEDTR Pathogenesis-related protein PR-1; TrEMBL-Plants: tr|I3SHL8|I3SHL8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0297700 | 23 | ||
| – | Pathogenesis-related protein 1; TAIR: AT4G30320.1 CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein; Swiss-Prot: sp|Q40374|PR1_MEDTR Pathogenesis-related protein PR-1; TrEMBL-Plants: tr|I3SXI8|I3SXI8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0297800 | 23 | ||
| – | Pathogenesis-related protein 1; TAIR: AT4G30320.1 CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein; Swiss-Prot: sp|Q40374|PR1_MEDTR Pathogenesis-related protein PR-1; TrEMBL-Plants: tr|I3SXI8|I3SXI8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0297800 | 23 | ||
| – | Pathogenesis-related protein 1; TAIR: AT3G09590.1 CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein; Swiss-Prot: sp|Q41359|PR1_SAMNI Pathogenesis-related protein PR-1 type; TrEMBL-Plants: tr|A0A072VJU7|A0A072VJU7_MEDTR CAP, cysteine-rich secretory protein, antigen 5; Found in the gene: LotjaGi5g1v0071700 | 22 | ||
| – | Pathogenesis-related protein 1-like; TAIR: AT4G33720.1 CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein; Swiss-Prot: sp|Q9ZNS4|PRB1_ARATH Pathogenesis-related protein 1; TrEMBL-Plants: tr|I3S886|I3S886_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0345200 | 22 | ||
| – | Pathogenesis-related protein 1; TAIR: AT4G33720.1 CAP (Cysteine-rich secretory proteins, Antigen 5, and Pathogenesis-related 1 protein) superfamily protein; Swiss-Prot: sp|P11670|PRB1_TOBAC Basic form of pathogenesis-related protein 1; TrEMBL-Plants: tr|I3T2D3|I3T2D3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0345300 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd05381 | CDD | 1 | 11.11 |