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IPR036605 is a Mago nashi superfamily.
<p>This superfamily was originally identified in Drosophila and called mago nashi, it is a strict maternal effect, grandchildless-like, gene [[cite:PUB00007284]]. The protein is an integral member of the exon junction complex (EJC). The EJC is a multiprotein complex that is deposited on spliced mRNAs after intron removal at a conserved position upstream of the exon-exon junction, and transported to the cytoplasm where it has been shown to influence translation, surveillance, and localization of the spliced mRNA. It consists of four core proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP and is supposed to be a binding platform for more peripherally and transiently associated factors along mRNA travel. Mago and Y14 form a stable heterodimer that stabilizes the complex by inhibiting eIF4AIII's ATPase activity. Mago-Y14 heterodimer has been shown to interact with the cytoplasmic protein PYM, an EJC disassembly factor, and specifically binds to the karyopherin nuclear receptor importin 13 [[cite:PUB00079498], [cite:PUB00079499], [cite:PUB00079500], [cite:PUB00079501], [cite:PUB00029696], [cite:PUB00079502], [cite:PUB00079503], [cite:PUB00007284], [cite:PUB00007286], [cite:PUB00007285], [cite:PUB00019831], [cite:PUB00079504], [cite:PUB00021760], [cite:PUB00030702], [cite:PUB00079505], [cite:PUB00079506], [cite:PUB00079507]].</p> <p>The human homologue has been shown to interact with an RNA binding protein, ribonucleoprotein rbm8 ([swissprot:Q9Y5S9]) [[cite:PUB00007285]]. An RNAi knockout of the Caenorhabditis elegans homologue causes masculinization of the germ line (Mog phenotype) hermaphrodites, suggesting it is involved in hermaphrodite germ-line sex determination [[cite:PUB00007286]] but the protein is also found in hermaphrodites and other organisms without a sexual differentiation.</p> <p>Structurally, Mago nashi has a β(4)-α-β(2)-α fold arranged into two layers (α/β) with an antiparallel β-sheet.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Protein mago nashi like; TAIR: AT1G02140.1 mago nashi family protein; Swiss-Prot: sp|O65806|MGN_EUPLA Protein mago nashi homolog; TrEMBL-Plants: tr|I3RZM3|I3RZM3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0068100 | 8 | ||
| – | Protein mago nashi like; TAIR: AT1G02140.1 mago nashi family protein; Swiss-Prot: sp|O23676|MGN_ARATH Protein mago nashi homolog; TrEMBL-Plants: tr|I3RZM3|I3RZM3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0068100 | 8 | ||
| – | Protein mago nashi like; TAIR: AT1G02140.1 mago nashi family protein; Swiss-Prot: sp|O23676|MGN_ARATH Protein mago nashi homolog; TrEMBL-Plants: tr|I1JMP2|I1JMP2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0068100 | 11 | ||
| – | Protein mago nashi like; TAIR: AT1G02140.1 mago nashi family protein; Swiss-Prot: sp|O65806|MGN_EUPLA Protein mago nashi homolog; TrEMBL-Plants: tr|I3T8H3|I3T8H3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0551700 | 8 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd11295 | CDD | 1 | 25.00 |