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IPR036980

Source: InterPro

Description

IPR036980 is a Ribonuclease P/MRP subunit Rpp29 superfamily.

<p>Ribonuclease P (Rnp) is a ubiquitous ribozyme that catalyzes a Mg2 -dependent hydrolysis to remove the 5'-leader sequence of precursor tRNA (pre-tRNA) in all three domains of life [[cite:PUB00006321]]. In bacteria, the catalytic RNA (typically ~120kDa) is aided by a small protein cofactor (~14kDa) [[cite:PUB00088366]]. Archaeal and eukaryote RNase P consist of a single RNA and archaeal RNase P has four or five proteins, while eukaryotic RNase P consists of 9 or 10 proteins. Eukaryotic and archaeal RNase P RNAs cooperatively function with protein subunits in catalysis [[cite:PUB00007201]].</p> <p>This entry includes p29 subunit (also known as Rpp29 or Pop4) of the Ribonuclease P complex [[cite:PUB00042726]]. Its homologues from eukaryotes are also a subunit of the RNase MRP complex. The structure of the RNase P subunit, Rpp29, from Methanobacterium thermoautotrophicum has been determined. Mth Rpp29 is a member of the oligonucleotide/oligosaccharide binding fold family. It contains a structured β-barrel core and unstructured N- and C-terminal extensions bearing several highly conserved amino acid residues that could be involved in RNA contacts in the protein-RNA complex [[cite:PUB00028005]]. Rpp29 ([ec:3.1.26.5]) catalyses the endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. It interacts with the Rpp25 and Pop5 subunits.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003723
Molecular function RNA binding Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
Subterm of
GO:0004540
Molecular function Ribonuclease activity Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA.
Subterm of
GO:0008033
Biological process TRNA processing The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
Subterm of
GO:0030677
Cellular component Ribonuclease P complex A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi2g1v0448500.1
– Ribonuclease P protein subunit p29; TAIR: AT2G43190.1 ribonuclease P family protein; Swiss-Prot: sp|Q9CR08|RPP29_MOUSE Ribonuclease P protein subunit p29; TrEMBL-Plants: tr|I1LG21|I1LG21_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0448500
Domains
10
LotjaGi2g1v0448500.2
– Ribonuclease P protein subunit p29; TAIR: AT2G43190.1 ribonuclease P family protein; Swiss-Prot: sp|Q9CR08|RPP29_MOUSE Ribonuclease P protein subunit p29; TrEMBL-Plants: tr|I1LG21|I1LG21_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0448500
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 50.00