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IPR037022

Source: InterPro

Description

IPR037022 is a Formyl transferase, C-terminal domain superfamily.

<p>Methionyl-tRNA formyltransferase ([ec:2.1.2.9]) transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP. This family also includes formyltetrahydrofolate dehydrogenases, which produce formate from formyl-tetrahydrofolate. These enzymes contain an N-terminal domain in common with other formyl transferase enzymes ([interpro:IPR002376]). The C-terminal domain has an open β-barrel fold [[cite:PUB00014118]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0009058
Biological process Biosynthetic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
Subterm of
GO:0016742
Molecular function Hydroxymethyl-, formyl- and related transferase activity Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor).
Subterm of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi2g1v0237200.1
– Methionyl-tRNA formyltransferase; TAIR: AT1G66520.1 formyltransferase; Swiss-Prot: sp|Q65JS5|FMT_BACLD Methionyl-tRNA formyltransferase; TrEMBL-Plants: tr|A0A0L9T444|A0A0L9T444_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0237200
Domains
24

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd08704 CDD 1 100.00