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IPR011034

Source: InterPro

Description

IPR011034 is a Formyl transferase-like, C-terminal domain superfamily.

<p>Methionyl-tRNA formyltransferase (FMT) ([ec:2.1.2.9]) transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP. This family also includes formyltetrahydrofolate dehydrogenases, which produce formate from formyl-tetrahydrofolate. These enzymes contain an N-terminal domain in common with other formyl transferase enzymes ([interpro:IPR002376]). The C-terminal domain has an open β-barrel fold [[cite:PUB00014118]].</p> <p>The C-terminal domain of FMT structurally resembles methylpurine-DNA glycosylases (MPG). Human 3-methyladenine DNA glycosylase (AAG) catalyses the first step of base excision repair by cleaving damaged bases from DNA, excising a chemically diverse selection of substrate bases damaged by alkylation or deamination [[cite:PUB00014119]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003824
Molecular function Catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
Subterm of

Associated Lotus transcripts 4

Transcript Name Description Predicted domains Domain count
Lj1g3v4361120.1
– PREDICTED: DNA-3-methyladenine glycosylase-like isoform X1 [Cicer arietinum] gi|502109262|ref|XP_004493604.1|
Domains
8
Lj2g3v0917320.1
– PREDICTED: methionyl-tRNA formyltransferase-like isoform X2 [Cicer arietinum] gi|502158762|ref|XP_004511272.1|
Domains
19
LotjaGi1g1v0279000.1
– DNA-3-methyladenine glycosylase; TAIR: AT3G12040.1 DNA-3-methyladenine glycosylase (MAG); Swiss-Prot: sp|Q39147|3MG_ARATH DNA-3-methyladenine glycosylase; TrEMBL-Plants: tr|I1N9A6|I1N9A6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0279000
Domains
11
LotjaGi2g1v0237200.1
– Methionyl-tRNA formyltransferase; TAIR: AT1G66520.1 formyltransferase; Swiss-Prot: sp|Q65JS5|FMT_BACLD Methionyl-tRNA formyltransferase; TrEMBL-Plants: tr|A0A0L9T444|A0A0L9T444_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0237200
Domains
24

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd08704 CDD 1 25.00