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IPR037353 is a Histone methyltransferase complex subunit ASH2.
<p>The trithorax-group (trxG) protein Ash2 from C. elegans (or ASH2L in mammals) is a component of the Set1/Ash2 histone methyltransferase (HMT) complex that methylates 'Lys-4' of histone H3, a mark associated with epigenetic transcriptional activation [[cite:PUB00033478], [cite:PUB00086798]]. Mammals posses several SET1 family proteins (MLL1-4, SET1A, and SET1B). ASH2L is a core component of all the resulting mammalian histone H3K4 methyltransferase complexes, including mixed lineage leukemia (MLL) complexes [[cite:PUB00086799]].</p> <p>S. cerevisiae Bre2 and Aspergillus fumigatus CclA are homologous to Ash2 [[cite:PUB00019348], [cite:PUB00152816]]. TRAUCO (TRO) is the homologue from Arabidopsis, which is required for early embryogenesis [[cite:PUB00086800]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Set1C/COMPASS complex | A conserved protein complex that catalyzes methylation of histone H3. In Saccharomyces the complex contains Shg1p, Sdc1p, Swd1p, Swd2p, Swd3p, Spp1p, Bre2p, and the trithorax-related Set1p; in mammals it contains the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30. | ||
| Biological process | Histone H3-K4 methylation | The modification of histone H3 by addition of one or more methyl groups to lysine at position 4 of the histone. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Set1/Ash2 histone methyltransferase complex subunit ASH2; TAIR: AT1G51450.1 TRAUCO; Swiss-Prot: sp|Q9C8J7|TRO_ARATH Protein TRAUCO; TrEMBL-Plants: tr|I1LPA8|I1LPA8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0536500 | 16 | ||
| – | Set1/Ash2 histone methyltransferase complex subunit ASH2; TAIR: AT1G51450.1 TRAUCO; Swiss-Prot: sp|Q9C8J7|TRO_ARATH Protein TRAUCO; TrEMBL-Plants: tr|V7ADB2|V7ADB2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0536500 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 50.00 |