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IPR037813 is a Transcription initiation factor TFIID subunit 2.
<p>Transcription initiation factor TFIID subunit 2 (TAF2) is a component of the general purpose transcription factor complex TFIID [[cite:PUB00087656], [cite:PUB00087622]]. This entry includes TAF2 from animals, plants and fungi.</p> <p>In yeast, TAF2 functions as a component of the DNA-binding general transcription factor complex TFIID. Its binding to a promoter, whether or not it contains a TATA element, represents the initial step in pre-initiation complex (PIC) formation. TAF2 plays a crucial role in regulating gene expression by RNA polymerase II through various mechanisms, including interaction with transcription activators, recognition and selectivity of core promoters, interactions with TFIIA and TFIIB, chromatin modification via histone acetylation by TAF1, facilitation of DNA unwinding, and initiation of transcription. In mammals, the TAF2 basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription [[cite:PUB00101058]]. It recognises and binds to promoters with or without a TATA box via its TBP subunit (TATA-box-binding protein), promoting the assembly of the PIC [[cite:PUB00101058]]. The complex comprises TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12, and TAF13 [[cite:PUB00101058], [cite:PUB00160919], [cite:PUB00125866]]. TAF2, in particular, forms a promoter DNA-binding subcomplex with TAF7 and TAF1 [[cite:PUB00101058], [cite:PUB00125866]].</p> <p>The DNA-binding general transcription factor complex TFIID is central to the initiation of DNA-dependent RNA polymerase II transcription. TFIID is the only general transcription initiation factor that bind to the TATA box. The binding of TFIID to the TATA-box is the first step in the formation of a complex able to initiate transcription [[cite:PUB00087636]]. TFIID consists of the TATA binding protein (TBP) and 14 TBP-associated factors (TAFs). One copy of each TAF1, TAF2, TAF3, TAF7, TAF8, TAF11, TAF13, two copies of each TAF4, TAF5, TAF6, TAF9, TAF10, TAF12, and three copies of TAF14 [[cite:PUB00087622]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Cellular component | Transcription factor TFIID complex | A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Transcription initiation factor TFIID subunit 2; TAIR: AT1G73960.1 TBP-associated factor 2; Swiss-Prot: sp|Q8LPF0|TAF2_ARATH Transcription initiation factor TFIID subunit 2; TrEMBL-Plants: tr|A0A1J7I063|A0A1J7I063_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0263300_LC | 2 | ||
| – | Transcription initiation factor TFIID subunit 2; TAIR: AT1G73960.1 TBP-associated factor 2; Swiss-Prot: sp|Q8LPF0|TAF2_ARATH Transcription initiation factor TFIID subunit 2; TrEMBL-Plants: tr|K7KNH3|K7KNH3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0263600 | 13 | ||
| – | Transcription initiation factor TFIID subunit 2; TAIR: AT1G73960.1 TBP-associated factor 2; Swiss-Prot: sp|Q8LPF0|TAF2_ARATH Transcription initiation factor TFIID subunit 2; TrEMBL-Plants: tr|V7CAF2|V7CAF2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi4g1v0263600 | 11 | ||
| – | Transcription initiation factor TFIID subunit 2; TAIR: AT1G73960.1 TBP-associated factor 2; Swiss-Prot: sp|Q8LPF0|TAF2_ARATH Transcription initiation factor TFIID subunit 2; TrEMBL-Plants: tr|K7KNH3|K7KNH3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0063100_LC | 14 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |