Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR037919 is a UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110kDa subunit.
<p>The UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase (OGT; [ec:2.4.1.255]) is a heterotrimer of one 78kDa subunit and two 110kDa subunits. OGT catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in a protein. Substrate proteins include histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. The consequences of this form of glycosylation are diverse, including insulin resistance in muscle and adipocyte cells (brought about by inhibiting the 'Thr-308' phosphorylation of AKT1) [[cite:PUB00087866]]; regulation of glycolysis by inhibiting PFKL activity [[cite:PUB00087867]]; in the cell cycle O-glycosylation stabilizes ARNTL/BMAL1 and CLOCK, preventing their ubiquitination and subsequent degradation [[cite:PUB00087868]]; glycosylation of HCFC1 and interaction with TET proteins promotes binding of the SET1/COMPASS methyltransferase SETD1A to chromatin [[cite:PUB00087869]]; and H2B GlcNAcylation is a histone modification that facilitates H2BK120 monoubiquitination [[cite:PUB00087870]]. It is a component of several complexes, including MLL5-L, NSL [[cite:PUB00060167]] and THAP1/THAP3-HCFC1-OGT [[cite:PUB00060556]].</p> <p>This entry represents the 110kDa subunit which has thirteen tetratricopeptide (TPR) repeats that are required for substrate binding and oligomerization [[cite:PUB00038020]].</p> <p>The NSL complex is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription. The complex is composed of at least MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1 [[cite:PUB00060167]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Protein O-linked glycosylation | A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan. | ||
| Molecular function | Transferase activity, transferring glycosyl groups | Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Tetratricopeptide repeat (TPR)-like superfamily protein; TAIR: AT3G04240.1 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|Q9M8Y0|SEC_ARATH Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC; TrEMBL-Plants: tr|G7I5N5|G7I5N5_MEDTR Peptide-N-acetylglucosaminyltransferase; Found in the gene: LotjaGi5g1v0205100 | 23 | ||
| – | Tetratricopeptide repeat (TPR)-containing protein; TAIR: AT3G04240.1 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|Q9M8Y0|SEC_ARATH Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC; TrEMBL-Plants: tr|G7I5N5|G7I5N5_MEDTR Peptide-N-acetylglucosaminyltransferase; Found in the gene: LotjaGi5g1v0205100 | 18 | ||
| – | Tetratricopeptide repeat (TPR)-like superfamily protein; TAIR: AT3G04240.1 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|Q9M8Y0|SEC_ARATH Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC; TrEMBL-Plants: tr|G7I5N5|G7I5N5_MEDTR Peptide-N-acetylglucosaminyltransferase; Found in the gene: LotjaGi5g1v0205100 | 22 | ||
| – | Tetratricopeptide repeat (TPR)-like superfamily protein; TAIR: AT3G04240.1 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|Q9M8Y0|SEC_ARATH Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC; TrEMBL-Plants: tr|G7I5N5|G7I5N5_MEDTR Peptide-N-acetylglucosaminyltransferase; Found in the gene: LotjaGi5g1v0205100 | 22 | ||
| – | Tetratricopeptide repeat (TPR)-like superfamily protein; TAIR: AT3G04240.1 Tetratricopeptide repeat (TPR)-like superfamily protein; Swiss-Prot: sp|Q9M8Y0|SEC_ARATH Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SEC; TrEMBL-Plants: tr|G7I5N5|G7I5N5_MEDTR Peptide-N-acetylglucosaminyltransferase; Found in the gene: LotjaGi5g1v0205100 | 22 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF48452 | SUPERFAMILY | 1 | 20.00 |