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IPR038469 is a tRNAHis guanylyltransferase Thg1 superfamily.
<p>tRNA His molecules are unusual in having an extra 5' GMP residue (G(-1)) that, in eukaryotes, is added after transcription and RNase P cleavage. Incorporation of this G(-1) residue is a rare example of nucleotide addition occurring at an RNA 5' end in a normal phosphodiester linkage. In Saccharomyces cerevisiae, YGR024c (Thg1p) protein is responsible for this guanylyltransferase reaction [[cite:PUB00020433]]. It catalyses the guanylyltransferase step of G(-1) addition using a ppp-tRNA His substrate, and appears to catalyse the activation step using p-tRNA His and ATP. Thus, it catalyses phosphodiester bond formation at the 5' end of RNAs, formally in a 3'-5' direction [[cite:PUB00020433]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | TRNA(His) guanylyltransferase; TAIR: AT2G32320.1 tRNAHis guanylyltransferase; Swiss-Prot: sp|F4IRQ5|THG1_ARATH tRNA(His) guanylyltransferase 1; TrEMBL-Plants: tr|A0A151R6C7|A0A151R6C7_CAJCA Putative tRNA(His) guanylyltransferase; Found in the gene: LotjaGi5g1v0055000 | 10 | ||
| – | TRNA(His) guanylyltransferase; TAIR: AT2G32320.1 tRNAHis guanylyltransferase; Swiss-Prot: sp|F4IRQ5|THG1_ARATH tRNA(His) guanylyltransferase 1; TrEMBL-Plants: tr|A0A151R6C7|A0A151R6C7_CAJCA Putative tRNA(His) guanylyltransferase; Found in the gene: LotjaGi5g1v0055000 | 10 | ||
| – | TRNA(His) guanylyltransferase; TAIR: AT2G32320.1 tRNAHis guanylyltransferase; Swiss-Prot: sp|F4ISV6|THG2_ARATH tRNA(His) guanylyltransferase 2; TrEMBL-Plants: tr|A0A0S3T8E1|A0A0S3T8E1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0041500 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR12729:SF6 | PANTHER | 1 | 33.33 |