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IPR007537

Source: InterPro

Description

IPR007537 is a tRNAHis guanylyltransferase Thg1.

<p>tRNA His molecules are unusual in having an extra 5' GMP residue (G(-1)) that, in eukaryotes, is added after transcription and RNase P cleavage. Incorporation of this G(-1) residue is a rare example of nucleotide addition occurring at an RNA 5' end in a normal phosphodiester linkage. In Saccharomyces cerevisiae, YGR024c (Thg1p) protein is responsible for this guanylyltransferase reaction [[cite:PUB00020433]]. It catalyses the guanylyltransferase step of G(-1) addition using a ppp-tRNA His substrate, and appears to catalyse the activation step using p-tRNA His and ATP. Thus, it catalyses phosphodiester bond formation at the 5' end of RNAs, formally in a 3'-5' direction [[cite:PUB00020433]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000287
Molecular function Magnesium ion binding Interacting selectively and non-covalently with magnesium (Mg) ions.
Subterm of
GO:0006400
Biological process TRNA modification The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
Subterm of
GO:0008193
Molecular function TRNA guanylyltransferase activity Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs.
Subterm of

Associated Lotus transcripts 6

Transcript Name Description Predicted domains Domain count
Lj5g3v0523190.1
– PREDICTED: tRNA(His) guanylyltransferase 1-like isoform X1 [Cicer arietinum] gi|502113614|ref|XP_004494705.1|
Domains
8
Lj5g3v0523190.2
– PREDICTED: tRNA(His) guanylyltransferase 1-like isoform X1 [Cicer arietinum] gi|502113614|ref|XP_004494705.1|
Domains
8
Lj6g3v0291920.1
– PREDICTED: tRNA(His) guanylyltransferase 1-like isoform X1 [Cicer arietinum] gi|502113614|ref|XP_004494705.1|
Domains
8
LotjaGi5g1v0055000.1
– TRNA(His) guanylyltransferase; TAIR: AT2G32320.1 tRNAHis guanylyltransferase; Swiss-Prot: sp|F4IRQ5|THG1_ARATH tRNA(His) guanylyltransferase 1; TrEMBL-Plants: tr|A0A151R6C7|A0A151R6C7_CAJCA Putative tRNA(His) guanylyltransferase; Found in the gene: LotjaGi5g1v0055000
Domains
10
LotjaGi5g1v0055000.2
– TRNA(His) guanylyltransferase; TAIR: AT2G32320.1 tRNAHis guanylyltransferase; Swiss-Prot: sp|F4IRQ5|THG1_ARATH tRNA(His) guanylyltransferase 1; TrEMBL-Plants: tr|A0A151R6C7|A0A151R6C7_CAJCA Putative tRNA(His) guanylyltransferase; Found in the gene: LotjaGi5g1v0055000
Domains
10
LotjaGi6g1v0041500.1
– TRNA(His) guanylyltransferase; TAIR: AT2G32320.1 tRNAHis guanylyltransferase; Swiss-Prot: sp|F4ISV6|THG2_ARATH tRNA(His) guanylyltransferase 2; TrEMBL-Plants: tr|A0A0S3T8E1|A0A0S3T8E1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0041500
Domains
10

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
PTHR12729:SF6 PANTHER 1 16.67