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IPR024956 is a tRNAHis guanylyltransferase catalytic domain.
<p>The Thg1 protein from Saccharomyces cerevisiae is responsible for adding a GMP residue to the 5' end of tRNA His [[cite:PUB00020433]]. The catalytic domain of Thg1 contains a RRM (ferredoxin) fold palm domain, just like the viral RNA-dependent RNA polymerases, reverse transcriptases, family A and B DNA polymerases, adenylyl cyclases, diguanylate cyclases (GGDEF domain) and the predicted polymerase of the CRISPR system [[cite:PUB00057251]]. Thg1 possesses an active site with three acidic residues that chelate Mg++ cations [[cite:PUB00057251]]. Thg1 likely catalyses polymerisation using a similar mechanism to the 5'-3' polymerases [[cite:PUB00057251], [cite:PUB00057252]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Magnesium ion binding | Interacting selectively and non-covalently with magnesium (Mg) ions. | ||
| Biological process | TRNA modification | The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. | ||
| Molecular function | TRNA guanylyltransferase activity | Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: tRNA(His) guanylyltransferase 1-like isoform X1 [Cicer arietinum] gi|502113614|ref|XP_004494705.1| | 8 | ||
| – | PREDICTED: tRNA(His) guanylyltransferase 1-like isoform X1 [Cicer arietinum] gi|502113614|ref|XP_004494705.1| | 8 | ||
| – | PREDICTED: tRNA(His) guanylyltransferase 1-like isoform X1 [Cicer arietinum] gi|502113614|ref|XP_004494705.1| | 8 | ||
| – | TRNA(His) guanylyltransferase; TAIR: AT2G32320.1 tRNAHis guanylyltransferase; Swiss-Prot: sp|F4IRQ5|THG1_ARATH tRNA(His) guanylyltransferase 1; TrEMBL-Plants: tr|A0A151R6C7|A0A151R6C7_CAJCA Putative tRNA(His) guanylyltransferase; Found in the gene: LotjaGi5g1v0055000 | 10 | ||
| – | TRNA(His) guanylyltransferase; TAIR: AT2G32320.1 tRNAHis guanylyltransferase; Swiss-Prot: sp|F4IRQ5|THG1_ARATH tRNA(His) guanylyltransferase 1; TrEMBL-Plants: tr|A0A151R6C7|A0A151R6C7_CAJCA Putative tRNA(His) guanylyltransferase; Found in the gene: LotjaGi5g1v0055000 | 10 | ||
| – | TRNA(His) guanylyltransferase; TAIR: AT2G32320.1 tRNAHis guanylyltransferase; Swiss-Prot: sp|F4ISV6|THG2_ARATH tRNA(His) guanylyltransferase 2; TrEMBL-Plants: tr|A0A0S3T8E1|A0A0S3T8E1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0041500 | 10 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| PTHR12729:SF6 | PANTHER | 1 | 16.67 |