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IPR038837 is a tRNA ligase 1.
<p>tRNA ligase 1 (RNL) is involved in the pre-tRNA splicing process in plants. Pre-tRNA splicing requires intron removal by an endonuclease, and a ligase for joining the resulting tRNA halves. In Arabidopsis, the endonuclease is encoded by two genes, SEN1 and SEN2 [[cite:PUB00088477]], and tRNA ligase is encoded by one gene, AtRNL [[cite:PUB00088472]]. Like fungal tRNA ligases, a plant tRNA ligase is a multifunctional enzyme consisting of three domains each with a different activity in the order: ligase, kinase and cyclic phosphodiesterase (CPDase). The polynucleotide kinase domain heals the broken ends to generate the 3'-OH, 2'-PO4, and 5'-PO4 required for sealing by the ligase domain [[cite:PUB00088473]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA ligase (ATP) activity | Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m). | ||
| Biological process | TRNA splicing, via endonucleolytic cleavage and ligation | Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | RNA ligase isoform 1; TAIR: AT1G07910.2 RNAligase; Swiss-Prot: sp|B9WK98|ARGJ_CANDC Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; TrEMBL-Plants: tr|A0A072UKW9|A0A072UKW9_MEDTR RNA ligase, putative; Found in the gene: LotjaGi2g1v0363400_LC | 3 | ||
| – | 3-dehydroquinate synthase; TAIR: AT1G07910.1 RNAligase; Swiss-Prot: sp|Q3IJA2|AROB_PSEHT 3-dehydroquinate synthase; TrEMBL-Plants: tr|A0A072UKW9|A0A072UKW9_MEDTR RNA ligase, putative; Found in the gene: LotjaGi2g1v0363400_LC | 3 | ||
| – | RNA ligase isoform 1; TAIR: AT1G07910.2 RNAligase; Swiss-Prot: sp|B9WK98|ARGJ_CANDC Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; TrEMBL-Plants: tr|A0A0R0E4L3|A0A0R0E4L3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0363400_LC | 10 | ||
| – | RNA ligase isoform 1; TAIR: AT1G07910.1 RNAligase; Swiss-Prot: sp|Q1RMS5|NXF1_BOVIN Nuclear RNA export factor 1; TrEMBL-Plants: tr|A0A1J7I1E9|A0A1J7I1E9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0363400_LC | 7 | ||
| – | 3-dehydroquinate synthase; TAIR: AT1G07910.1 RNAligase; Swiss-Prot: sp|Q3IJA2|AROB_PSEHT 3-dehydroquinate synthase; TrEMBL-Plants: tr|A0A072UKW9|A0A072UKW9_MEDTR RNA ligase, putative; Found in the gene: LotjaGi2g1v0363400_LC | 3 | ||
| – | 3-dehydroquinate synthase; TAIR: AT1G07910.1 RNAligase; Swiss-Prot: sp|Q3IJA2|AROB_PSEHT 3-dehydroquinate synthase; TrEMBL-Plants: tr|A0A072UKW9|A0A072UKW9_MEDTR RNA ligase, putative; Found in the gene: LotjaGi2g1v0363400_LC | 3 | ||
| – | RNA ligase isoform 1; TAIR: AT1G07910.2 RNAligase; Swiss-Prot: sp|B9WK98|ARGJ_CANDC Arginine biosynthesis bifunctional protein ArgJ, mitochondrial; TrEMBL-Plants: tr|A0A0R0E4L3|A0A0R0E4L3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0363400_LC | 10 | ||
| – | RNA ligase isoform 1; TAIR: AT1G07910.1 RNAligase; Swiss-Prot: sp|Q3IJA2|AROB_PSEHT 3-dehydroquinate synthase; TrEMBL-Plants: tr|A0A072UKW9|A0A072UKW9_MEDTR RNA ligase, putative; Found in the gene: LotjaGi2g1v0363400_LC | 3 | ||
| – | RNA ligase isoform 1; TAIR: AT1G07910.2 RNAligase; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|A0A072UKW9|A0A072UKW9_MEDTR RNA ligase, putative; Found in the gene: LotjaGi3g1v0364800 | 4 | ||
| – | RNA ligase isoform 1; TAIR: AT1G07910.2 RNAligase; Swiss-Prot: sp|Q9FR53|TOR_ARATH Serine/threonine-protein kinase TOR; TrEMBL-Plants: tr|A0A0R0E4L3|A0A0R0E4L3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0364800 | 10 | ||
| – | RNA ligase isoform 1; TAIR: AT1G07910.2 RNAligase; Swiss-Prot: sp|Q6D9J6|DSBD_PECAS Thiol:disulfide interchange protein DsbD; TrEMBL-Plants: tr|A0A0S3SCT5|A0A0S3SCT5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0365400_LC | 10 | ||
| – | RNA ligase, putative; TAIR: AT1G07910.2 RNAligase; Swiss-Prot: sp|Q8W486|Y1491_ARATH Uncharacterized protein At1g04910; TrEMBL-Plants: tr|A0A072UKW9|A0A072UKW9_MEDTR RNA ligase, putative; Found in the gene: LotjaGi3g1v0365500_LC | 4 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 8.33 |