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GO:0006298

View this GO term in other databases

Overview

Field Value
Namespace Biological process
Short description Mismatch repair
Full defintion A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.
Subterm of

Relationships

The relationship of GO:0006298 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
ISBN
Oxford Dictionary of Biochemistry and Molecular BiologyOxford Dictionary of Biochemistry and Molecular Biology

Anthony David Smith,Anthony Donald Smith · ISBN: 0198506732

Oxford University Press, USA, 2000 · 760 pages

This book provides a survey of current biochemistry and molecular biology in the form of a dictionary. It contains short but informative entries arranged under more than 17,000 headwords, providing fundamental but up-to-date information that is often difficult to locate in today'soverspecialized world. The book is intended as a handy reference of first resource for those seeking information outside their immediate knowledge area or for those who need to refresh their memory of fundamental knowledge. It gives the meanings of many terms used in molecular biology and describes the essential featuresof over approximately 2,000 enzymes and proteins, describing the reactions they catalyse or functions they perform, and includes filenames that facilitate the location of entires in databases of sequences. Many entries describe chemical compounds of relevance to biochemists, with approximately 950symbols and abbreviations. In addition, many physico-chemical laws, constants, and formulae are detailed. This revised edition has been fully up-dated in order to include the new information that has been discovered since the original edition was published in 1997.

PMID
Functional interactions and signaling properties of mammalian DNA mismatch repair proteins.Bellacosa A
Cell Death Differ. 2001 Nov; 8 (11): 1076–92.PMID: 11687886

The mismatch repair (MMR) system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. This function is critically dependent on the assembling of multimeric complexes involved in mismatch recognition and signal transduction to downstream repair events. In addition, MMR proteins coordinate a complex network of physical and functional interactions that mediate other DNA transactions, such as transcription-coupled repair, base excision repair and recombination. MMR proteins are also involved in activation of cell cycle checkpoint and induction of apoptosis when DNA damage overwhelms a critical threshold. For this reason, they play a role in cell death by alkylating agents and other chemotherapeutic drugs, including cisplatin. Inactivation of MMR genes in hereditary and sporadic cancer is associated with a mutator phenotype and inhibition of apoptosis. In the future, a deeper understanding of the molecular mechanisms and functional interactions of MMR proteins will lead to the development of more effective cancer prevention and treatment strategies.

Associated Lotus transcripts 46

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0104059.1
– PREDICTED: mutS protein homolog 5-like [Glycine max] gi|356553565|ref|XP_003545125.1|
GO terms
3
Lj0g3v0130849.1
– PREDICTED: DNA mismatch repair protein MSH1, mitochondrial-like [Cicer arietinum] gi|502122529|ref|XP_004497789.1|
GO terms
3
Lj0g3v0130859.1
– PREDICTED: DNA mismatch repair protein MSH1, mitochondrial-like [Cicer arietinum] gi|502122529|ref|XP_004497789.1|
GO terms
3
Lj0g3v0155879.1
– PREDICTED: DNA mismatch repair protein Mlh1-like [Glycine max] gi|356507690|ref|XP_003522597.1|
GO terms
3
Lj1g3v0246860.1
– PREDICTED: DNA mismatch repair protein MSH7-like [Cicer arietinum] gi|502163835|ref|XP_004512965.1|
GO terms
3
Lj1g3v4862830.1
– PREDICTED: DNA mismatch repair protein Msh6-1-like [Glycine max] gi|356572787|ref|XP_003554547.1|
GO terms
3
Lj1g3v4862840.1
– PREDICTED: DNA mismatch repair protein MSH6-like [Cicer arietinum] gi|502112702|ref|XP_004494416.1|
GO terms
3
Lj2g3v0777050.1
– PREDICTED: DNA mismatch repair protein MSH7-like [Cicer arietinum] gi|502163835|ref|XP_004512965.1|
GO terms
3
Lj2g3v0777050.2
– PREDICTED: DNA mismatch repair protein MSH7-like [Cicer arietinum] gi|502163835|ref|XP_004512965.1|
GO terms
3
Lj2g3v1600990.1
– MutL DNA mismatch repair protein [Medicago truncatula] gi|357484163|ref|XP_003612368.1|
GO terms
1
Lj2g3v1601010.1
– PREDICTED: DNA mismatch repair protein MLH3-like isoform X2 [Cicer arietinum] gi|502161762|ref|XP_004512276.1|
GO terms
2
Lj2g3v1601010.2
– PREDICTED: DNA mismatch repair protein MLH3-like isoform X2 [Cicer arietinum] gi|502161762|ref|XP_004512276.1|
GO terms
2
Lj2g3v1601010.3
– PREDICTED: DNA mismatch repair protein MLH3-like isoform X2 [Cicer arietinum] gi|502161762|ref|XP_004512276.1|
GO terms
2
Lj2g3v2001370.1
– PREDICTED: DNA mismatch repair protein MSH4-like isoform X2 [Cicer arietinum] gi|502160324|ref|XP_004511708.1|
GO terms
3
Lj2g3v2195520.1
– PREDICTED: mutS2 protein-like isoform X2 [Cicer arietinum] gi|502095766|ref|XP_004490532.1|
GO terms
3
Lj2g3v2195520.2
– PREDICTED: mutS2 protein-like isoform X2 [Cicer arietinum] gi|502095766|ref|XP_004490532.1|
GO terms
3
Lj2g3v2195520.3
– PREDICTED: mutS2 protein-like isoform X2 [Cicer arietinum] gi|502095766|ref|XP_004490532.1|
GO terms
3
Lj2g3v3184230.2
– DNA mismatch repair protein mutS [Medicago truncatula] gi|357494573|ref|XP_003617575.1|
GO terms
3
Lj3g3v0582180.1
– PREDICTED: mutS protein homolog 4-like [Glycine max] gi|356540540|ref|XP_003538746.1|
GO terms
3
Lj3g3v1957990.1
– PREDICTED: DNA mismatch repair protein MLH1-like [Cicer arietinum] gi|502127149|ref|XP_004499581.1|
GO terms
3
Lj4g3v0451120.1
– PREDICTED: mutS2 protein-like isoform 1 [Glycine max] gi|356521349|ref|XP_003529319.1|
GO terms
3
Lj4g3v0451120.2
– PREDICTED: mutS2 protein-like isoform 1 [Glycine max] gi|356521349|ref|XP_003529319.1|
GO terms
3
Lj4g3v1787050.1
– PREDICTED: DNA mismatch repair protein Msh2-like [Glycine max] gi|356563103|ref|XP_003549805.1|
GO terms
5
Lj4g3v1787050.2
– PREDICTED: DNA mismatch repair protein MSH2-like [Cicer arietinum] gi|502151706|ref|XP_004508573.1|
GO terms
5
Lj5g3v1631040.1
– PREDICTED: mismatch repair endonuclease PMS2-like [Glycine max] gi|356502864|ref|XP_003520235.1|
GO terms
3
Lj5g3v2013910.1
– PREDICTED: DNA mismatch repair protein MSH3-like isoform X1 [Cicer arietinum] gi|502119328|ref|XP_004496581.1|
GO terms
3
LotjaGi1g1v0027200.1
– DNA mismatch repair protein MutS; TAIR: AT3G20475.1 MUTS-homologue 5; Swiss-Prot: sp|F4JEP5|MSH5_ARATH DNA mismatch repair protein MSH5; TrEMBL-Plants: tr|K7M4I0|K7M4I0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0027200
GO terms
3
LotjaGi1g1v0027200.2
– DNA mismatch repair protein MutS; TAIR: AT3G20475.1 MUTS-homologue 5; Swiss-Prot: sp|F4JEP5|MSH5_ARATH DNA mismatch repair protein MSH5; TrEMBL-Plants: tr|K7M4I0|K7M4I0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0027200
GO terms
3
LotjaGi1g1v0127700.1
– DNA mismatch repair MUTS family protein; TAIR: AT5G54090.1 DNA mismatch repair protein MutS, type 2; Swiss-Prot: sp|P73625|MUTS2_SYNY3 Endonuclease MutS2; TrEMBL-Plants: tr|I1JH75|I1JH75_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0127700
GO terms
3
LotjaGi1g1v0127700.2
– DNA mismatch repair MUTS family protein; TAIR: AT5G54090.1 DNA mismatch repair protein MutS, type 2; Swiss-Prot: sp|P73625|MUTS2_SYNY3 Endonuclease MutS2; TrEMBL-Plants: tr|I1JH75|I1JH75_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0127700
GO terms
3
LotjaGi1g1v0760200.1
– DNA mismatch repair protein MutS; TAIR: AT4G02070.1 MUTS homolog 6; Swiss-Prot: sp|O04716|MSH6_ARATH DNA mismatch repair protein MSH6; TrEMBL-Plants: tr|A0A151RYF4|A0A151RYF4_CAJCA DNA mismatch repair protein Msh6-1; Found in the gene: LotjaGi1g1v0760200
GO terms
3
LotjaGi2g1v0214200.1
– DNA mismatch repair protein mutS; TAIR: AT3G24495.1 MUTS homolog 7; Swiss-Prot: sp|Q9SMV7|MSH7_ARATH DNA mismatch repair protein MSH7; TrEMBL-Plants: tr|G7KNH7|G7KNH7_MEDTR DNA mismatch repair protein msh6; Found in the gene: LotjaGi2g1v0214200
GO terms
3
LotjaGi2g1v0354500.1
– DNA mismatch repair protein mutL; TAIR: AT4G35520.2 MUTL protein homolog 3; Swiss-Prot: sp|F4JN26|MLH3_ARATH DNA mismatch repair protein MLH3; TrEMBL-Plants: tr|A0A0B2RU55|A0A0B2RU55_GLYSO DNA mismatch repair protein Mlh3; Found in the gene: LotjaGi2g1v0354500
GO terms
5
LotjaGi2g1v0421600.1
– DNA mismatch repair protein mutS; TAIR: AT4G17380.1 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|K7LMU8|K7LMU8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0421600
GO terms
3
LotjaGi2g1v0421600.2
– DNA mismatch repair protein mutS, putative; TAIR: AT4G17380.1 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|A0A151TJF2|A0A151TJF2_CAJCA MutS protein isogeny 4; Found in the gene: LotjaGi2g1v0421600
GO terms
3
LotjaGi2g1v0421600.3
– DNA mismatch repair protein mutS; TAIR: AT4G17380.2 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|A0A0R0HJU3|A0A0R0HJU3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0421600
GO terms
3
LotjaGi2g1v0421600.4
– DNA mismatch repair protein mutS; TAIR: AT4G17380.1 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|K7LMU8|K7LMU8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0421600
GO terms
3
LotjaGi2g1v0421600.5
– DNA mismatch repair protein mutS; TAIR: AT4G17380.2 MUTS-like protein 4; Swiss-Prot: sp|F4JP48|MSH4_ARATH DNA mismatch repair protein MSH4; TrEMBL-Plants: tr|A0A0R0HJU3|A0A0R0HJU3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0421600
GO terms
3
LotjaGi3g1v0335500.1
– DNA mismatch repair protein MutL; TAIR: AT4G09140.1 MUTL-homologue 1; Swiss-Prot: sp|Q9ZRV4|MLH1_ARATH DNA mismatch repair protein MLH1; TrEMBL-Plants: tr|I1JZC3|I1JZC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0335500
GO terms
5
LotjaGi3g1v0335500.2
– DNA mismatch repair protein MutL; TAIR: AT4G09140.1 MUTL-homologue 1; Swiss-Prot: sp|Q9ZRV4|MLH1_ARATH DNA mismatch repair protein MLH1; TrEMBL-Plants: tr|I1JZC3|I1JZC3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0335500
GO terms
5
LotjaGi4g1v0055400.1
– DNA mismatch repair protein MutS2; TAIR: AT1G65070.2 DNA mismatch repair protein MutS, type 2; Swiss-Prot: sp|P73625|MUTS2_SYNY3 Endonuclease MutS2; TrEMBL-Plants: tr|I1KLI9|I1KLI9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0055400
GO terms
3
LotjaGi4g1v0263800.1
– DNA mismatch repair protein mutS; TAIR: AT3G18524.1 MUTS homolog 2; Swiss-Prot: sp|O24617|MSH2_ARATH DNA mismatch repair protein MSH2; TrEMBL-Plants: tr|I1MUG2|I1MUG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0263800
GO terms
5
LotjaGi4g1v0263800.2
– DNA mismatch repair protein mutS; TAIR: AT3G18524.1 MUTS homolog 2; Swiss-Prot: sp|O24617|MSH2_ARATH DNA mismatch repair protein MSH2; TrEMBL-Plants: tr|I1MUG2|I1MUG2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0263800
GO terms
5
LotjaGi5g1v0251500.1
– MutL DNA mismatch repair protein; TAIR: AT4G02460.1 DNA mismatch repair protein; Swiss-Prot: sp|Q941I6|PMS1_ARATH DNA mismatch repair protein PMS1; TrEMBL-Plants: tr|I1JFI1|I1JFI1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0251500
GO terms
5
LotjaGi5g1v0301900.1
– DNA mismatch repair protein mutS; TAIR: AT4G25540.1 homolog of DNA mismatch repair protein MSH3; Swiss-Prot: sp|O65607|MSH3_ARATH DNA mismatch repair protein MSH3; TrEMBL-Plants: tr|A0A072VPI7|A0A072VPI7_MEDTR DNA mismatch repair MSH3-like protein; Found in the gene: LotjaGi5g1v0301900
GO terms
3
LotjaGi6g1v0010300.1
– DNA mismatch repair protein mutS; TAIR: AT3G24320.1 MUTL protein homolog 1; Swiss-Prot: sp|Q84LK0|MSH1_ARATH DNA mismatch repair protein MSH1, mitochondrial; TrEMBL-Plants: tr|G7I6Q0|G7I6Q0_MEDTR DNA mismatch repair protein; Found in the gene: LotjaGi6g1v0010300
GO terms
3

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0030983
Molecular function Mismatched DNA binding 1 2.17