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IPR039177

Source: InterPro

Description

IPR039177 is a Nonsense-mediated mRNA decay factor SMG9.

<p>Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that detects and degrades mRNAs containing premature translation termination codons. Protein SMG9 is a component of the SMG1C protein kinase complex (along with SMG1 and SMG8) which is recruited to stalled ribosomes. SMG8 and SMG9 suppress SMG1 kinase activity in the isolated SMG1 complex [[cite:PUB00054170]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0000184
Biological process Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins.
Subterm of

Associated Lotus transcripts 2

Transcript Name Description Predicted domains Domain count
LotjaGi2g1v0449700.1
– TIR-NBS-LRR class disease resistance protein; TAIR: AT5G18370.1 disease resistance protein (TIR-NBS-LRR class) family protein; Swiss-Prot: sp|Q5PQS6|SMG9_RAT Protein SMG9; TrEMBL-Plants: tr|V7CID3|V7CID3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi2g1v0449700
Domains
5
LotjaGi6g1v0175200.1
– TIR-NBS-LRR class disease resistance protein; TAIR: AT5G18370.1 disease resistance protein (TIR-NBS-LRR class) family protein; Swiss-Prot: sp|Q5PQS6|SMG9_RAT Protein SMG9; TrEMBL-Plants: tr|V7CID3|V7CID3_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0175200
Domains
5

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
SSF52540 SUPERFAMILY 1 50.00