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IPR039778 is a Programmed cell death protein 4.
<p>Programmed cell death protein 4 (PDCD4) binds to eukaryotic initiation factor 4A (eIF4A), inhibits translation initiation, and acts as a tumour suppressor. It contains two C-terminal MA3 domains that bind specifically to the eIF4A N-terminal domain (eIF4A-NTD) [[cite:PUB00049359], [cite:PUB00051704], [cite:PUB00050443]].</p> <p>This entry also includes MRF1/2/3/4 from plants. They are involved in target of rapamycin (TOR)-egulated translation control, especially under energy-deficient conditions [[cite:PUB00093083]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Negative regulation of transcription, DNA-templated | Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Programmed cell death protein 4; TAIR: AT1G22730.1 MA3 domain-containing protein; Swiss-Prot: sp|Q98TX3|PDCD4_CHICK Programmed cell death protein 4; TrEMBL-Plants: tr|A0A151SX73|A0A151SX73_CAJCA Programmed cell death protein 4; Found in the gene: LotjaGi2g1v0118200 | 12 | ||
| – | Programmed cell death protein 4; TAIR: AT5G63190.1 MA3 domain-containing protein; Swiss-Prot: sp|Q98TX3|PDCD4_CHICK Programmed cell death protein 4; TrEMBL-Plants: tr|A0A151TE45|A0A151TE45_CAJCA Programmed cell death protein 4; Found in the gene: LotjaGi4g1v0225400 | 11 | ||
| – | Programmed cell death protein 4; TAIR: AT5G63190.1 MA3 domain-containing protein; Swiss-Prot: sp|Q53EL6|PDCD4_HUMAN Programmed cell death protein 4; TrEMBL-Plants: tr|A0A0L9TQG9|A0A0L9TQG9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0225400 | 11 | ||
| – | Programmed cell death protein 4; TAIR: AT5G63190.1 MA3 domain-containing protein; Swiss-Prot: sp|Q98TX3|PDCD4_CHICK Programmed cell death protein 4; TrEMBL-Plants: tr|A0A151TE45|A0A151TE45_CAJCA Programmed cell death protein 4; Found in the gene: LotjaGi4g1v0225400 | 11 | ||
| – | Programmed cell death protein 4; TAIR: AT5G63190.1 MA3 domain-containing protein; Swiss-Prot: sp|Q53EL6|PDCD4_HUMAN Programmed cell death protein 4; TrEMBL-Plants: tr|A0A0L9TQG9|A0A0L9TQG9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0225400 | 11 | ||
| – | Programmed cell death protein 4; TAIR: AT5G63190.1 MA3 domain-containing protein; Swiss-Prot: sp|Q98TX3|PDCD4_CHICK Programmed cell death protein 4; TrEMBL-Plants: tr|A0A151TE45|A0A151TE45_CAJCA Programmed cell death protein 4; Found in the gene: LotjaGi4g1v0225400 | 11 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF48371 | SUPERFAMILY | 1 | 16.67 |