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IPR040183 is a THUMP domain-containing protein 1-like.
<p>This family contains THUMP domain-only proteins including THUMP domain-containing protein 1 and Saccharomyces cerevisiae Tan1. Tan1 is non essential and has been shown to be required for the formation of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA. THUMPD1 is also an adapter required for NAT10-dependent tRNA acetylation [[cite:PUB00076725]]. The THUMP domain is named after thiouridine synthases, methylases and PSUSs. The domain consists of about 110 amino acid residues. It is predicted to be an RNA-binding domain and probably functions by delivering a variety of RNA modification enzymes to their targets [[cite:PUB00090669], [cite:PUB00090670], [cite:PUB00007072]].</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. | ||
| Biological process | TRNA modification | The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | THUMP domain-containing protein 1 like; TAIR: AT5G12410.1 THUMP domain-containing protein; Swiss-Prot: sp|Q99J36|THUM1_MOUSE THUMP domain-containing protein 1; TrEMBL-Plants: tr|G7K999|G7K999_MEDTR THUMP domain protein; Found in the gene: LotjaGi2g1v0443500 | 11 | ||
| – | THUMP domain-containing protein 1; TAIR: AT1G09290.1 hypothetical protein; Swiss-Prot: sp|Q9VZD8|THUM1_DROME THUMP domain-containing protein 1 homolog; TrEMBL-Plants: tr|D2KTV6|D2KTV6_LOTJA Putative uncharacterized protein; Found in the gene: LotjaGi5g1v0347300 | 7 | ||
| – | THUMP domain-containing protein 1; TAIR: AT1G09290.1 hypothetical protein; Swiss-Prot: sp|Q9VZD8|THUM1_DROME THUMP domain-containing protein 1 homolog; TrEMBL-Plants: tr|D2KTV6|D2KTV6_LOTJA Putative uncharacterized protein; Found in the gene: LotjaGi5g1v0347300 | 9 | ||
| – | THUMP domain-containing protein 1; TAIR: AT1G09290.1 hypothetical protein; Swiss-Prot: sp|Q9VZD8|THUM1_DROME THUMP domain-containing protein 1 homolog; TrEMBL-Plants: tr|I3SZ74|I3SZ74_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0347300 | 9 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 25.00 |