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IPR040184

Source: InterPro

Description

IPR040184 is a Minichromosome maintenance protein 10.

<p>Minichromosome maintenance protein 10 (Mcm10) is a eukaryotic DNA replication factor that regulates the stability and chromatin association of DNA polymerase alpha [[cite:PUB00035418]]. It is required for DNA synthesis and for entry into or completion of S phase. It is associated with the DNA polymerase-alpha (pol-alpha) primase complex throughout the cell cycle, and is a nuclear chaperone for Cdc17, which is otherwise rapidly degraded [[cite:PUB00090674]]. It is also required for maintenance of transcriptional silencing [[cite:PUB00090675]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0003690
Molecular function Double-stranded DNA binding Interacting selectively and non-covalently with double-stranded DNA.
Subterm of
GO:0003697
Molecular function Single-stranded DNA binding Interacting selectively and non-covalently with single-stranded DNA.
Subterm of
GO:0006270
Biological process DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
Subterm of
Part of

Associated Lotus transcripts 1

Transcript Name Description Predicted domains Domain count
LotjaGi1g1v0559000.1
– Protein MCM10 like; TAIR: AT2G20980.1 minichromosome maintenance 10; Swiss-Prot: sp|Q0VBD2|MCM10_MOUSE Protein MCM10 homolog; TrEMBL-Plants: tr|A0A151RNG8|A0A151RNG8_CAJCA Protein MCM10 isogeny; Found in the gene: LotjaGi1g1v0559000
Domains
6

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 100.00