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IPR043127 is a Sec1-like, domain 3a.
<p>This superfamily represents the N-terminal region of domain 3 (called domain 3a) found in Sec1 and related proteins.</p> <p>Sec1-like molecules have been implicated in a variety of eukaryotic vesicle transport processes including neurotransmitter release by exocytosis [[cite:PUB00003457]]. They regulate vesicle transport by binding to a t-SNARE from the syntaxin family. This process is thought to prevent SNARE complex formation, a protein complex required for membrane fusion. Whereas Sec1 molecules are essential for neurotransmitter release and other secretory events, their interaction with syntaxin molecules seems to represent a negative regulatory step in secretion [[cite:PUB00007149]].</p> <p>The nSec1 polypeptide chain can be divided into three domains. The first domain, consists of a five-stranded parallel β-sheet flanked by five α-helices. The second domain, like the first one, has an α-β-α fold, however the β-sheet of domain 2 features five parallel strands with an additional antiparallel strand on one edge. The third domain is a large insertion between the third and fourth parallel strands of domain 2, and can be subdivided in two [[cite:PUB00024251]].</p> <p>Members of the Sec1 family include Sec1, Sly1, Slp1/Vps33, Vps45/Stt10 (yeast), Unc-18 (nematode), Munc-18b/muSec1, Munc-18c (mouse), Rop (Drosophila), Munc-18/n-Sec1/rbSec1A and rbSec1B (rat) [[cite:PUB00003457]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Vacuolar protein sorting-associated protein 45 like; TAIR: AT1G77140.1 vacuolar protein sorting 45; Swiss-Prot: sp|O49048|VPS45_ARATH Vacuolar protein sorting-associated protein 45 homolog; TrEMBL-Plants: tr|A0A151QRQ6|A0A151QRQ6_CAJCA Vacuolar protein sorting-associated protein 45 isogeny; Found in the gene: LotjaGi1g1v0274000 | 14 | ||
| – | Vacuolar protein sorting-associated protein 45 like; TAIR: AT1G77140.1 vacuolar protein sorting 45; Swiss-Prot: sp|O49048|VPS45_ARATH Vacuolar protein sorting-associated protein 45 homolog; TrEMBL-Plants: tr|A0A151QRQ6|A0A151QRQ6_CAJCA Vacuolar protein sorting-associated protein 45 isogeny; Found in the gene: LotjaGi1g1v0274000 | 14 | ||
| – | SNARE-interacting protein KEULE; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|I1LGL2|I1LGL2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0427100 | 16 | ||
| – | SNARE-interacting protein KEULE; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|K7K529|K7K529_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0427100 | 13 | ||
| – | SNARE-interacting protein KEULE; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|K7K529|K7K529_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0427100 | 17 | ||
| – | SEC1 family transport protein SLY1; TAIR: AT2G17980.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9SL48|SLY1_ARATH SEC1 family transport protein SLY1; TrEMBL-Plants: tr|K7KPU4|K7KPU4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0029100 | 16 | ||
| – | SEC1 family transport protein SLY1; TAIR: AT2G17980.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9SL48|SLY1_ARATH SEC1 family transport protein SLY1; TrEMBL-Plants: tr|K7KPU4|K7KPU4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0029100 | 16 | ||
| – | SEC1 family transport protein SLY1; TAIR: AT2G17980.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9SL48|SLY1_ARATH SEC1 family transport protein SLY1; TrEMBL-Plants: tr|K7KPU4|K7KPU4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0029100 | 16 | ||
| – | SEC1 family transport protein SLY1; TAIR: AT2G17980.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9SL48|SLY1_ARATH SEC1 family transport protein SLY1; TrEMBL-Plants: tr|K7KPU4|K7KPU4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0029100 | 16 | ||
| – | SEC1 family transport protein SLY1; TAIR: AT2G17980.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9SL48|SLY1_ARATH SEC1 family transport protein SLY1; TrEMBL-Plants: tr|K7KPU4|K7KPU4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0029100 | 13 | ||
| – | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
| – | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
| – | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
| – | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
| – | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
| – | SNARE-interacting KEULE-like protein; TAIR: AT1G12360.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q9C5X3|KEULE_ARATH SNARE-interacting protein KEULE; TrEMBL-Plants: tr|G7JLB0|G7JLB0_MEDTR SNARE-interacting KEULE-like protein; Found in the gene: LotjaGi4g1v0213400 | 15 | ||
| – | Vacuolar protein-sorting-associated protein 33-like protein; TAIR: AT3G54860.1 Sec1/munc18-like (SM) proteins superfamily; Swiss-Prot: sp|Q94KJ7|VPS33_ARATH Vacuolar protein-sorting-associated protein 33 homolog; TrEMBL-Plants: tr|V7BXY6|V7BXY6_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0270800 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TRANSMEMBRANE | Phobius | 1 | 5.88 |